Neurovascular coupling is preserved in chronic stroke recovery after targeted photothrombosis.
Neurovascular coupling is preserved in chronic stroke recovery after targeted photothrombosis.
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靶向光栓塞后，神经血管耦合保留在慢性中风恢复中。
DOI：
10.1016/j.nicl.2023.103377
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Boas DA
中科院分区：
文献类型：
--
作者：
Sunil S;Jiang J;Shah S;Kura S;Kilic K;Erdener SE;Ayata C;Devor A;Boas DA
荧光和内在信号成像相结合，研究脑卒中恢复过程中的神经血管耦合。神经血管耦合在慢性卒中中得以保留，这表明功能性神经影像学反映了神经活动。中风导致全球脑振荡的增加，显示钙和血流动力学之间的不同模式。功能性神经影像学测量脑活动的血流动力学反应，在监测中风患者的恢复和指导恢复期间的康复方面具有很大的潜力。然而，中风后的血流动力学反应相对于健康受试者的反应几乎总是改变的，并且仍然不清楚这些改变是否反映了潜在的脑生理学，或者这些改变是否纯粹是由于血管损伤。换句话说，我们不知道中风对神经血管耦合的影响，因此我们使用功能性神经影像学准确解释中风病理生理的能力有限。为了应对这一挑战，我们同时捕捉神经活动，通过荧光钙成像，和血流动力学，通过内在的光学信号成像，在纵向中风恢复。我们的数据表明，在恢复的慢性阶段（中风后2周和4周），神经血管耦合被保留，并类似于中风前的神经血管耦合。这表明，功能性神经影像学忠实地反映了慢性卒中的潜在神经活动。此外，脑卒中恢复亚急性期的神经血管耦合可预测长期行为结局。中风还导致全球脑震荡的增加，这表明神经活动和血液动力学之间的不同模式。对侧半球的神经兴奋性增加与对侧半球内连接性增加相关。此外，血流动力学振荡的亚急性增加与感觉运动结局的改善相关。总的来说，这些结果支持使用脑卒中后脑活动的血流动力学指标来预测功能和行为结果。
Fluorescence and intrinsic signal imaging were combined to study neurovascular coupling in stroke recovery. Neurovascular coupling was preserved in chronic stroke suggesting that functional neuroimaging represents neural activity. Stroke resulted in increases in global brain oscillations that showed distinct patterns between calcium and hemodynamics. Functional neuroimaging, which measures hemodynamic responses to brain activity, has great potential for monitoring recovery in stroke patients and guiding rehabilitation during recovery. However, hemodynamic responses after stroke are almost always altered relative to responses in healthy subjects and it is still unclear if these alterations reflect the underlying brain physiology or if the alterations are purely due to vascular injury. In other words, we do not know the effect of stroke on neurovascular coupling and are therefore limited in our ability to use functional neuroimaging to accurately interpret stroke pathophysiology. To address this challenge, we simultaneously captured neural activity, through fluorescence calcium imaging, and hemodynamics, through intrinsic optical signal imaging, during longitudinal stroke recovery. Our data suggest that neurovascular coupling was preserved in the chronic phase of recovery (2 weeks and 4 weeks post-stoke) and resembled pre-stroke neurovascular coupling. This indicates that functional neuroimaging faithfully represents the underlying neural activity in chronic stroke. Further, neurovascular coupling in the sub-acute phase of stroke recovery was predictive of long-term behavioral outcomes. Stroke also resulted in increases in global brain oscillations, which showed distinct patterns between neural activity and hemodynamics. Increased neural excitability in the contralesional hemisphere was associated with increased contralesional intrahemispheric connectivity. Additionally, sub-acute increases in hemodynamic oscillations were associated with improved sensorimotor outcomes. Collectively, these results support the use of hemodynamic measures of brain activity post-stroke for predicting functional and behavioral outcomes.
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