Nicotinic Acetylcholine Receptors Control Encoding and Retrieval of Associative Recognition Memory through Plasticity in the Medial Prefrontal Cortex.
Nicotinic Acetylcholine Receptors Control Encoding and Retrieval of Associative Recognition Memory through Plasticity in the Medial Prefrontal Cortex.
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DOI：
10.1016/j.celrep.2018.03.016
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发表时间：
2018-03-27
期刊：
影响因子：
8.8
通讯作者：
Bashir ZI
中科院分区：
文献类型：
--
作者：
Sabec MH;Wonnacott S;Warburton EC;Bashir ZI
内侧前额叶皮层中表达的烟碱乙酰胆碱受体（nAChRs）在认知功能中具有关键作用。然而，nAChRs是否需要联想识别记忆和nAChRs可能有助于记忆处理的机制尚不清楚。我们证明，nAChRs在前额叶皮层表现出亚型特定的角色，在联想记忆编码和检索。我们提出的证据表明，这些单独的作用nAChRs可能依赖于双向调制的可塑性在突触输入到前额叶皮层，是必不可少的联想识别记忆。前额叶α7 nAChR对联想识别记忆的编码至关重要前额叶α4β2 nAChR对联想识别记忆的检索是必需的α7和α4β2 nAChR门在前额叶-前额叶突触的双向可塑性双向可塑性是nAChR在联想识别中的作用的基础Sabec et al.揭示了前额叶烟碱受体亚型在长期联想识别记忆的不同阶段中的功能差异，其涉及到突触可塑性的双向调节。
Nicotinic acetylcholine receptors (nAChRs) expressed in the medial prefrontal cortex have critical roles in cognitive function. However, whether nAChRs are required for associative recognition memory and the mechanisms by which nAChRs may contribute to mnemonic processing are not known. We demonstrate that nAChRs in the prefrontal cortex exhibit subtype-specific roles in associative memory encoding and retrieval. We present evidence that these separate roles of nAChRs may rely on bidirectional modulation of plasticity at synaptic inputs to the prefrontal cortex that are essential for associative recognition memory. Prefrontal α7 nAChRs are critical for encoding of associative recognition memory Prefrontal α4β2 nAChRs are required for retrieval of associative recognition memory α7 and α4β2 nAChRs gate bidirectional plasticity at hippocampal-prefrontal synapses Bidirectional plasticity underlies the role of nAChR in associative recognition Sabec et al. reveal a divergence in function of prefrontal nicotinic receptor subtypes in different stages of long-term associative recognition memory that relates to bidirectional modulation of synaptic plasticity at hippocampal-prefrontal synapses.
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