Cartwheel assembly.

Cartwheel assembly.
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DOI:
10.1098/rstb.2013.0458
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发表时间:
2014-09-05
期刊:
Philosophical transactions of the Royal Society of London. Series B, Biological sciences
影响因子:
--
通讯作者:
Hirono M
Hirono M
中科院分区:
其他
文献类型:
--
作者:
Hirono M

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侧手翻是一种亚中心粒结构,由中心轮毂和位于中心粒近端的九个径向排列的辐条组成。它出现在中心粒组装过程的初始阶段,作为第一个九重对称结构。侧手翻在 50 多年前首次被描述,但直到最近,它在建立中心粒九重对称性方面的关键作用才被证明。此后,在了解其精细结构和组装机制方面取得了重大进展。最重要的是,侧手翻的中心部分是九重对称性的起源,它是由 SAS-6 蛋白的九个二聚体自缔合形成的。这一发现与侧手翻其他成分的新数据一起,为中心体生物学开辟了新的途径。
The cartwheel is a subcentriolar structure consisting of a central hub and nine radially arranged spokes, located at the proximal end of the centriole. It appears at the initial stage of the centriole assembly process as the first ninefold symmetrical structure. The cartwheel was first described more than 50 years ago, but it is only recently that its pivotal role in establishing the ninefold symmetry of the centriole was demonstrated. Significant progress has since been made in understanding its fine structure and assembly mechanism. Most importantly, the central part of the cartwheel, from which the ninefold symmetry originates, is shown to form by self-association of nine dimers of the protein SAS-6. This finding, together with emerging data on other components of the cartwheel, has opened new avenues in centrosome biology.
DOI: 10.1083/jcb.54.2.246
发表时间: 1972-08
影响因子: 7.8
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