Improved cellular specificity of plasmonic nanobubbles versus nanoparticles in heterogeneous cell systems.
Improved cellular specificity of plasmonic nanobubbles versus nanoparticles in heterogeneous cell systems.
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DOI：
10.1371/journal.pone.0034537
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Lapotko DO
中科院分区：
文献类型：
--
作者：
Lukianova-Hleb EY;Ren X;Constantinou PE;Danysh BP;Shenefelt DL;Carson DD;Farach-Carson MC;Kulchitsky VA;Wu X;Wagner DS;Lapotko DO
The limited specificity of nanoparticle (NP) uptake by target cells associated with a disease is one of the principal challenges of nanomedicine. Using the threshold mechanism of plasmonic nanobubble (PNB) generation and enhanced accumulation and clustering of gold nanoparticles in target cells, we increased the specificity of PNB generation and detection in target versus non-target cells by more than one order of magnitude compared to the specificity of NP uptake by the same cells. This improved cellular specificity of PNBs was demonstrated in six different cell models representing diverse molecular targets such as epidermal growth factor receptor, CD3 receptor, prostate specific membrane antigen and mucin molecule MUC1. Thus PNBs may be a universal method and nano-agent that overcome the problem of non-specific uptake of NPs by non-target cells and improve the specificity of NP-based diagnostics, therapeutics and theranostics at the cell level.
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影响因子：
3.5
作者：
Hleb, E. Y.;Lapotko, D. O.
通讯作者：
Lapotko, D. O.
影响因子：
10.8
作者：
Anderson, Lindsey J. E.;Hansen, Eric;Lukianova-Hleb, Ekaterina Y.;Hafner, Jason H.;Lapotko, Dmitri O.
通讯作者：
Lapotko, Dmitri O.
影响因子：
10.8
作者：
El-Sayed, IH;Huang, XH;El-Sayed, MA
通讯作者：
El-Sayed, MA
影响因子：
10.8
作者：
Huschka R;Neumann O;Barhoumi A;Halas NJ
通讯作者：
Halas NJ
影响因子：
29.4
作者：
Hauck, Tanya S.;Jennings, Travis L.;Chan, Warren C. W.
通讯作者：
Chan, Warren C. W.