Optically guided controlled release from liposomes with tunable plasmonic nanobubbles.
Optically guided controlled release from liposomes with tunable plasmonic nanobubbles.
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DOI：
10.1016/j.jconrel.2010.02.012
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发表时间：
2010-06-01
影响因子：
10.8
通讯作者：
Lapotko, Dmitri O.
中科院分区：
文献类型：
--
作者：
Anderson, Lindsey J. E.;Hansen, Eric;Lukianova-Hleb, Ekaterina Y.;Hafner, Jason H.;Lapotko, Dmitri O.
使用含有分子负载和金纳米粒子（NP）的脂质体对一种新的光引导控释方法进行了实验评估。将纳米粒子暴露在短激光脉冲下，在纳米粒子周围诱导瞬时蒸汽泡（等离子体纳米气泡），从而破坏脂质体并喷射其分子内容物。通过改变纳米气泡的寿命和尺寸以及激光脉冲的通量来调节释放功效。纳米气泡的光学散射与分子释放相关并用于引导释放。荧光显微镜直接监测了两种荧光蛋白从单个脂质体中的释放，而等离子体纳米气泡的产生则通过光学散射技术进行成像和测量。等离子纳米气泡诱导的释放被发现是一种机械、非热过程，需要单个激光脉冲并在毫秒时间内喷射脂质体内容物，而不损坏分子货物，并且可以通过激光脉冲的通量进行控制。
A new method of optically guided controlled release was experimentally evaluated with liposomes containing a molecular load and gold nanoparticles (NPs). NPs were exposed to short laser pulses to induce transient vapor bubbles around the NPs, plasmonic nanobubbles, in order to disrupt the liposome and eject its molecular contents. The release efficacy was tuned by varying the lifetime and size of the nanobubble with the fluence of the laser pulse. Optical scattering by nanobubbles correlated to the molecular release and was used to guide the release. The release of two fluorescent proteins from individual liposomes has been directly monitored by fluorescence microscopy, while the generation of the plasmonic nanobubbles was imaged and measured with optical scattering techniques. Plasmonic nanobubble-induced release was found to be a mechanical, nonthermal process that requires a single laser pulse and ejects of the liposome contents within a millisecond timescale without damage to the molecular cargo and that can be controlled through the fluence of laser pulse.
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影响因子：
3.4
作者：
Ciani, L;Ristori, S;Martini, G
通讯作者：
Martini, G
影响因子：
3.5
作者：
Hleb, E. Y.;Lapotko, D. O.
通讯作者：
Lapotko, D. O.
DOI：
10.1016/j.ijheatmasstransfer.2004.08.012
发表时间：
2005-01-01
影响因子：
5.2
作者：
Lapotko, D;Lukianova, E
通讯作者：
Lukianova, E
DOI：
10.2217/nnm.09.59
发表时间：
2009-10
期刊：
Nanomedicine (London, England)
影响因子：
--
作者：
Lapotko D
通讯作者：
Lapotko D
影响因子：
4.9
作者：
Gullotti E;Yeo Y
通讯作者：
Yeo Y