Cutting edge: influence of Tmevpg1, a long intergenic noncoding RNA, on the expression of Ifng by Th1 cells.
Cutting edge: influence of Tmevpg1, a long intergenic noncoding RNA, on the expression of Ifng by Th1 cells.
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DOI：
10.4049/jimmunol.1200774
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发表时间：
2012-09-01
期刊：
影响因子：
--
通讯作者：
Aune TM
中科院分区：
文献类型：
--
作者：
Collier SP;Collins PL;Williams CL;Boothby MR;Aune TM
The majority of the genome is noncoding and was believed to be nonfunctional. However, it is now appreciated that transcriptional control of protein coding genes resides within these noncoding regions. Thousands of genes encoding long intergenic noncoding RNAs (lincRNAs) have been recently identified throughout the genome, which positively or negatively regulate transcription of neighboring target genes. Both TMEVPG1 and its mouse orthologue encode lincRNAs and are positioned near the interferon gamma gene (IFNG). Here we show that transcription of both mouse and human TMEVPG1 genes is Th1 selective and dependent upon Stat4 and T-bet, transcription factors that drive the Th1 differentiation program. Ifng expression is partially restored in Stat4−/−Tbx21−/− cells through co-expression of T-bet and Tmevpg1 and Tmevpg1 expression contributes to but alone is not sufficient to drive Th1-dependent Ifng expression. Our results suggest that TMEVPG1 belongs to the general class of lincRNAs that positively regulate gene transcription.
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