Stem cell platforms for regenerative medicine.
Stem cell platforms for regenerative medicine.
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DOI：
10.1111/j.1752-8062.2009.00096.x
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发表时间：
2009-06
期刊：
影响因子：
--
通讯作者：
Terzic A
中科院分区：
文献类型：
--
作者：
Nelson TJ;Behfar A;Yamada S;Martinez-Fernandez A;Terzic A
与人口老龄化相关的慢性退行性疾病的流行要求开发有效的组织修复方法。由于不同的干细胞直接有助于先天愈合，从头组织重建的能力为再生医学带来了很有前途的作用。事实上，从胚胎到成体祖细胞的一系列天然干细胞来源最近已被鉴定具有独特的再生特征。再生医疗设备的可及性和适用性已经通过核重编程工程化的干细胞进一步扩展。通过移植功能组织的替代、移植祖细胞的再生或激活内源性自我修复机制的再生策略，再生医学的首要目标是将干细胞平台转化为实践，并实现仅限于姑息性干预的疾病的治愈。利用每个平台的全部潜力将优化基于干细胞的生物制剂与个体患者的疾病特异性生态位环境的匹配，以最大限度地提高长期管理的质量，同时最大限度地减少对连续治疗的需求。因此，新兴的发现科学加上临床转化的反馈，有望改变医学，提供安全有效的干细胞生物治疗药物，为不治之症提供个性化的解决方案。
The pandemic of chronic degenerative diseases associated with aging demographics mandates development of effective approaches for tissue repair. As diverse stem cells directly contribute to innate healing, the capacity for de novo tissue reconstruction harbors a promising role for regenerative medicine. Indeed, a spectrum of natural stem cell sources ranging from embryonic to adult progenitors has been recently identified with unique characteristics for regeneration. The accessibility and applicability of the regenerative armamentarium has been further expanded with stem cells engineered by nuclear reprogramming. Through strategies of replacement to implant functional tissues, regeneration to transplant progenitor cells or rejuvenation to activate endogenous self-repair mechanisms, the overarching goal of regenerative medicine is to translate stem cell platforms into practice and achieve cures for diseases limited to palliative interventions. Harnessing the full potential of each platform will optimize matching stem cell-based biologics with the disease-specific niche environment of individual patients to maximize the quality of long-term management, while minimizing the needs for adjunctive therapy. Emerging discovery science with feedback from clinical translation is therefore poised to transform medicine offering safe and effective stem cell biotherapeutics to enable personalized solutions for incurable diseases.
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DOI：
10.1084/jem.20061916
发表时间：
2007-02-19
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Behfar A;Perez-Terzic C;Faustino RS;Arrell DK;Hodgson DM;Yamada S;Puceat M;Niederländer N;Alekseev AE;Zingman LV;Terzic A
通讯作者：
Terzic A
影响因子：
20.3
作者：
Martinez, Caridad;Hofmann, Ted J.;Horwitz, Edwin M.
通讯作者：
Horwitz, Edwin M.
影响因子：
46.9
作者：
Kroon, Evert;Martinson, Laura A.;Baetge, Emmanuel E.
通讯作者：
Baetge, Emmanuel E.
DOI：
10.1007/bf02698057
发表时间：
2006-01-01
期刊：
STEM CELL REVIEWS
影响因子：
--
作者：
Hall, Vanessa J.;Stojkovic, Miodrag
通讯作者：
Stojkovic, Miodrag
影响因子：
4.4
作者：
Matsunaga, Yusuke;Fukuma, Daiki;Senju, Satoru
通讯作者：
Senju, Satoru