T Cells That Help B Cells in Chronically Inflamed Tissues.
T Cells That Help B Cells in Chronically Inflamed Tissues.
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DOI：
10.3389/fimmu.2018.01924
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发表时间：
2018
影响因子：
7.3
通讯作者：
Rao DA
中科院分区：
文献类型：
--
作者：
Rao DA
慢性炎症组织通常会聚集淋巴细胞，促进局部T细胞与b细胞的相互作用。这些聚集体的范围从小的、排列松散的淋巴细胞簇到大的、有组织的异位淋巴样结构。在某些情况下，异位淋巴样结构会形成生发中心，其中含有高表达Bcl6、CXCR5、PD-1和ICOS的原型T滤泡辅助细胞（Tfh）。然而，在许多慢性炎症组织中，与B细胞相互作用的T细胞在表面表型、迁移能力和转录调节方面与Tfh细胞表现出实质性的差异。这篇综述讨论了从多种疾病和模型中观察到的组织浸润T细胞产生与B细胞帮助相关的因子，包括IL-21和B细胞趋化剂CXCL13，但它们与Tfh细胞的相似性有很大差异。特别关注PD-1hi CXCR5−Bcl6low T外周辅助（Tph）细胞群在类风湿关节炎中，通过趋化因子受体（如CCR2）的表达浸润炎症滑膜，并通过CXCL13和IL-21增强滑膜B细胞反应。在这些情况下，调节CD4+ T细胞产生CXCL13和IL-21的因素也进行了讨论。了解慢性炎症组织中可以为B细胞提供帮助的T细胞群的范围，对于识别不同炎症条件下的这些细胞以及优化B细胞辅助T细胞的广泛或选择性治疗靶向至关重要。
Chronically inflamed tissues commonly accrue lymphocyte aggregates that facilitate local T cell-B cell interactions. These aggregates can range from small, loosely arranged lymphocyte clusters to large, organized ectopic lymphoid structures. In some cases, ectopic lymphoid structures develop germinal centers that house prototypical T follicular helper (Tfh) cells with high expression of Bcl6, CXCR5, PD-1, and ICOS. However, in many chronically inflamed tissues, the T cells that interact with B cells show substantial differences from Tfh cells in their surface phenotypes, migratory capacity, and transcriptional regulation. This review discusses observations from multiple diseases and models in which tissue-infiltrating T cells produce factors associated with B cell help, including IL-21 and the B cell chemoattractant CXCL13, yet vary dramatically in their resemblance to Tfh cells. Particular attention is given to the PD-1hi CXCR5− Bcl6low T peripheral helper (Tph) cell population in rheumatoid arthritis, which infiltrates inflamed synovium through expression of chemokine receptors such as CCR2 and augments synovial B cell responses via CXCL13 and IL-21. The factors that regulate CD4+ T cell production of CXCL13 and IL-21 in these settings are also discussed. Understanding the range of T cell populations that can provide help to B cells within chronically inflamed tissues is essential to recognize these cells in diverse inflammatory conditions and to optimize either broad or selective therapeutic targeting of B cell-helper T cells.
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影响因子：
7.8
作者：
Berek, C;Kim, H J
通讯作者：
Kim, H J
影响因子：
16.6
作者：
Vu Van D;Beier KC;Pietzke LJ;Al Baz MS;Feist RK;Gurka S;Hamelmann E;Kroczek RA;Hutloff A
通讯作者：
Hutloff A
DOI：
10.4049/jimmunol.1001983
发表时间：
2011-02-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Chang A;Henderson SG;Brandt D;Liu N;Guttikonda R;Hsieh C;Kaverina N;Utset TO;Meehan SM;Quigg RJ;Meffre E;Clark MR
通讯作者：
Clark MR
影响因子：
3.7
作者：
Carpio VH;Opata MM;Montañez ME;Banerjee PP;Dent AL;Stephens R
通讯作者：
Stephens R
影响因子：
13.3
作者：
Blokland, Sofie L. M.;Hillen, Maarten R.;van Roon, Joel A. G.
通讯作者：
van Roon, Joel A. G.