Reduced global cerebral oxygen metabolic rate in sickle cell disease and chronic anemias.
Reduced global cerebral oxygen metabolic rate in sickle cell disease and chronic anemias.
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DOI：
10.1002/ajh.26203
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发表时间：
2021-08-01
影响因子：
12.8
通讯作者：
Wood JC
中科院分区：
文献类型：
--
作者：
Vu C;Bush A;Choi S;Borzage M;Miao X;Nederveen AJ;Coates TD;Wood JC
贫血是世界上最常见的血液疾病。在患有慢性贫血的患者中，如镰状细胞病或重型地中海贫血，脑血流量增加以补偿氧含量的减少。然而，慢性贫血对氧摄取分数（OEF）和脑氧代谢率（CMRO 2）的影响尚不清楚。在这项研究中，我们使用脑氧合和流量的MRI指标检查了47名镰状细胞性贫血受试者（年龄21.7±7.1，女性45%），27名非镰状细胞性贫血受试者（年龄25.0±10.4，女性52%）和44名健康对照者（年龄26.4±10.6，女性71%）。使用相差MRI测量静息脑血流量，而使用具有疾病适当校准的T2弛豫自旋标记（TRUST）MRI测量OEF和CMRO 2。我们观察到镰状细胞病和其他慢性贫血患者的OEF和CMRO 2降低，（镰状细胞病分别为27.4±4.1%和3.39±0.71 mL O2/100 g/min，与对照组（36.7±6.0%和4.00±0.65 mL O2/100 g/min）相比，其他贫血组为30.8±5.2%和3.53±0.64 mL O2/100 g/min。CMRO 2受损与贫血严重程度成正比。我们进一步证明了惊人的一致性，目前的工作与汇总的历史数据，从患者有广泛的病因，他们的贫血。脑氧摄取和代谢减少与新出现的数据一致，这些数据表明镰状细胞病患者的非营养性血流或生理分流增加。
Anemia is the most common blood disorder in the world. In patients with chronic anemia, such as sickle cell disease or major thalassemia, cerebral blood flow increases to compensate for decreased oxygen content. However, the effects of chronic anemia on oxygen extraction fraction (OEF) and cerebral metabolic rate of oxygen (CMRO2) are less well understood. In this study, we examined 47 sickle-cell anemia subjects (age 21.7±7.1, female 45%), 27 non-sickle anemic subjects (age 25.0±10.4, female 52%) and 44 healthy controls (age 26.4±10.6, female 71%) using MRI metrics of brain oxygenation and flow. Phase contrast MRI was used to measure resting cerebral blood flow, while T2-relaxation-under-spin-tagging (TRUST) MRI with disease appropriate calibrations were used to measure OEF and CMRO2. We observed that patients with sickle cell disease and other chronic anemias have decreased OEF and CMRO2 (respectively 27.4±4.1% and 3.39±0.71 mL O2/100g/min in sickle cell disease, 30.8±5.2% and 3.53±0.64 mL O2/100g/min in other anemias) compared to controls (36.7±6.0% and 4.00±0.65 mL O2/100g/min). Impaired CMRO2 was proportional to the degree of anemia severity. We further demonstrate striking concordance of the present work with pooled historical data from patients having broad etiologies for their anemia. The reduced cerebral oxygen extraction and metabolism are consistent with emerging data demonstrating increased non-nutritive flow, or physiological shunting, in sickle cell disease patients.
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影响因子：
3.3
作者：
Bush A;Vu C;Choi S;Borzage M;Miao X;Li W;Qin Q;Nederveen AJ;Coates TD;Wood JC
通讯作者：
Wood JC
影响因子：
3.7
作者：
Colombatti R;Lucchetta M;Montanaro M;Rampazzo P;Ermani M;Talenti G;Baracchini C;Favero A;Basso G;Manara R;Sainati L
通讯作者：
Sainati L
DOI：
10.1097/00004647-199701000-00009
发表时间：
1997-01-01
影响因子：
6.3
作者：
Buxton, RB;Frank, LR
通讯作者：
Frank, LR
影响因子：
3.3
作者：
Bush AM;Coates TD;Wood JC
通讯作者：
Wood JC
短暂性缺氧模型显示，使用粗体MRI和近红外光谱法脑血管损伤。
DOI：
10.1002/jmri.27210
发表时间：
2020-11
期刊：
Journal of magnetic resonance imaging : JMRI
影响因子：
--
作者：
Coloigner J;Vu C;Borzage M;Bush A;Choi S;Miao X;Chai Y;Galarza C;Lepore N;Tamrazi B;Coates TD;Wood JC
通讯作者：
Wood JC