Investigation of gene-environment interactions in relation to tic severity.
Investigation of gene-environment interactions in relation to tic severity.
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DOI：
10.1007/s00702-021-02396-y
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发表时间：
2021-11
期刊：
影响因子：
--
通讯作者：
Hoekstra PJ
中科院分区：
文献类型：
--
作者：
Abdulkadir M;Yu D;Osiecki L;King RA;Fernandez TV;Brown LW;Cheon KA;Coffey BJ;Garcia-Delgar B;Gilbert DL;Grice DE;Hagstrøm J;Hedderly T;Heyman I;Hong HJ;Huyser C;Ibanez-Gomez L;Kim YK;Kim YS;Koh YJ;Kook S;Kuperman S;Leventhal B;Madruga-Garrido M;Maras A;Mir P;Morer A;Münchau A;Plessen KJ;Roessner V;Shin EY;Song DH;Song J;Visscher F;Zinner SH;Mathews CA;Scharf JM;Tischfield JA;Heiman GA;Dietrich A;Hoekstra PJ
抽动秽语综合征（TS）是一种遗传和环境因素共同作用的神经精神疾病。我们调查了遗传基因位点先前牵连在抽动秽语综合征和相关疾病的相互作用与产前和围产期逆境有关抽动的严重程度，使用一个病例（N = 518）的设计。我们评估了98个单核苷酸多态性（SNPs），这些SNPs选自：（I）TS全基因组关联研究（GWAS）中的最高SNPs;（II）强迫症（OCD）、注意力缺陷/多动障碍（ADHD）和自闭症谱系障碍（ASD）GWAS中的最高SNPs;（III）先前涉及TS候选基因研究的SNPs;（IV）先前涉及OCD或ASD的SNPs;（IV）先前涉及自闭症谱系障碍（ASD）的SNPs。以及（V）标记神经递质相关候选基因中的SNP。线性回归模型被用来检查单核苷酸多态性对抽搐严重程度的主要影响，以及这些单核苷酸多态性与累积的产前和围产期逆境评分的相互作用。在复制样品（N = 678）中寻找满足显著性阈值（在校正多次测试后）的SNP的复制。一个SNP（rs7123010），以前在TS荟萃分析中涉及，与较高的抽搐严重程度显着相关。我们发现rs6539267的基因-环境相互作用，另一个顶级TS GWAS SNP。这些发现没有被独立复制。我们的研究强调了TS GWAS在基因环境研究中的未来潜力。在线版本包含补充材料，可通过10.1007/s 00702 -021-02396-y获得。
Tourette syndrome (TS) is a neuropsychiatric disorder with involvement of genetic and environmental factors. We investigated genetic loci previously implicated in Tourette syndrome and associated disorders in interaction with pre- and perinatal adversity in relation to tic severity using a case-only (N = 518) design. We assessed 98 single-nucleotide polymorphisms (SNPs) selected from (I) top SNPs from genome-wide association studies (GWASs) of TS; (II) top SNPs from GWASs of obsessive–compulsive disorder (OCD), attention-deficit/hyperactivity disorder (ADHD), and autism spectrum disorder (ASD); (III) SNPs previously implicated in candidate-gene studies of TS; (IV) SNPs previously implicated in OCD or ASD; and (V) tagging SNPs in neurotransmitter-related candidate genes. Linear regression models were used to examine the main effects of the SNPs on tic severity, and the interaction effect of these SNPs with a cumulative pre- and perinatal adversity score. Replication was sought for SNPs that met the threshold of significance (after correcting for multiple testing) in a replication sample (N = 678). One SNP (rs7123010), previously implicated in a TS meta-analysis, was significantly related to higher tic severity. We found a gene–environment interaction for rs6539267, another top TS GWAS SNP. These findings were not independently replicated. Our study highlights the future potential of TS GWAS top hits in gene–environment studies. The online version contains supplementary material available at 10.1007/s00702-021-02396-y.
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DOI：
10.1002/ajmg.b.31246
发表时间：
2011-12-01
影响因子：
2.8
作者：
Hinney, Anke;Scherag, Andre;Hebebrand, Johannes
通讯作者：
Hebebrand, Johannes
影响因子：
3.5
作者：
Anney R;Klei L;Pinto D;Almeida J;Bacchelli E;Baird G;Bolshakova N;Bölte S;Bolton PF;Bourgeron T;Brennan S;Brian J;Casey J;Conroy J;Correia C;Corsello C;Crawford EL;de Jonge M;Delorme R;Duketis E;Duque F;Estes A;Farrar P;Fernandez BA;Folstein SE;Fombonne E;Gilbert J;Gillberg C;Glessner JT;Green A;Green J;Guter SJ;Heron EA;Holt R;Howe JL;Hughes G;Hus V;Igliozzi R;Jacob S;Kenny GP;Kim C;Kolevzon A;Kustanovich V;Lajonchere CM;Lamb JA;Law-Smith M;Leboyer M;Le Couteur A;Leventhal BL;Liu XQ;Lombard F;Lord C;Lotspeich L;Lund SC;Magalhaes TR;Mantoulan C;McDougle CJ;Melhem NM;Merikangas A;Minshew NJ;Mirza GK;Munson J;Noakes C;Nygren G;Papanikolaou K;Pagnamenta AT;Parrini B;Paton T;Pickles A;Posey DJ;Poustka F;Ragoussis J;Regan R;Roberts W;Roeder K;Roge B;Rutter ML;Schlitt S;Shah N;Sheffield VC;Soorya L;Sousa I;Stoppioni V;Sykes N;Tancredi R;Thompson AP;Thomson S;Tryfon A;Tsiantis J;Van Engeland H;Vincent JB;Volkmar F;Vorstman JA;Wallace S;Wing K;Wittemeyer K;Wood S;Zurawiecki D;Zwaigenbaum L;Bailey AJ;Battaglia A;Cantor RM;Coon H;Cuccaro ML;Dawson G;Ennis S;Freitag CM;Geschwind DH;Haines JL;Klauck SM;McMahon WM;Maestrini E;Miller J;Monaco AP;Nelson SF;Nurnberger JI Jr;Oliveira G;Parr JR;Pericak-Vance MA;Piven J;Schellenberg GD;Scherer SW;Vicente AM;Wassink TH;Wijsman EM;Betancur C;Buxbaum JD;Cook EH;Gallagher L;Gill M;Hallmayer J;Paterson AD;Sutcliffe JS;Szatmari P;Vieland VJ;Hakonarson H;Devlin B
通讯作者：
Devlin B
影响因子：
11
作者：
Scharf, J. M.;Yu, D.;Mathews, C. A.;Neale, B. M.;Stewart, S. E.;Fagerness, J. A.;Evans, P.;Gamazon, E.;Edlund, C. K.;Service, S. K.;Tikhomirov, A.;Osiecki, L.;Illmann, C.;Pluzhnikov, A.;Konkashbaev, A.;Davis, L. K.;Han, B.;Crane, J.;Moorjani, P.;Crenshaw, A. T.;Parkin, M. A.;Reus, V. I.;Lowe, T. L.;Rangel-Lugo, M.;Chouinard, S.;Dion, Y.;Girard, S.;Cath, D. C.;Smit, J. H.;King, R. A.;Fernandez, T. V.;Leckman, J. F.;Kidd, K. K.;Kidd, J. R.;Pakstis, A. J.;State, M. W.;Herrera, L. D.;Romero, R.;Fournier, E.;Sandor, P.;Barr, C. L.;Phan, N.;Gross-Tsur, V.;Benarroch, F.;Pollak, Y.;Budman, C. L.;Bruun, R. D.;Erenberg, G.;Naarden, A. L.;Lee, P. C.;Weiss, N.;Kremeyer, B.;Berrio, G. B.;Campbell, D. D.;Cardona Silgado, J. C.;Ochoa, W. C.;Mesa Restrepo, S. C.;Muller, H.;Valencia Duarte, A. V.;Lyon, G. J.;Leppert, M.;Morgan, J.;Weiss, R.;Grados, M. A.;Anderson, K.;Davarya, S.;Singer, H.;Walkup, J.;Jankovic, J.;Tischfield, J. A.;Heiman, G. A.;Gilbert, D. L.;Hoekstra, P. J.;Robertson, M. M.;Kurlan, R.;Liu, C.;Gibbs, J. R.;Singleton, A.;Hardy, J.;Strengman, E.;Ophoff, R. A.;Wagner, M.;Moessner, R.;Mirel, D. B.;Posthuma, D.;Sabatti, C.;Eskin, E.;Conti, D. V.;Knowles, J. A.;Ruiz-Linares, A.;Rouleau, G. A.;Purcell, S.;Heutink, P.;Oostra, B. A.;McMahon, W. M.;Freimer, N. B.;Cox, N. J.;Pauls, D. L.
通讯作者：
Pauls, D. L.
影响因子：
9.8
作者：
Djordjevic, Djurdja;Pinard, Maxime;Yoon, Grace
通讯作者：
Yoon, Grace
DOI：
10.1007/s00406-017-0808-8
发表时间：
2018-04
影响因子：
4.7
作者：
Abdulkadir M;Londono D;Gordon D;Fernandez TV;Brown LW;Cheon KA;Coffey BJ;Elzerman L;Fremer C;Fründt O;Garcia-Delgar B;Gilbert DL;Grice DE;Hedderly T;Heyman I;Hong HJ;Huyser C;Ibanez-Gomez L;Jakubovski E;Kim YK;Kim YS;Koh YJ;Kook S;Kuperman S;Leventhal B;Ludolph AG;Madruga-Garrido M;Maras A;Mir P;Morer A;Müller-Vahl K;Münchau A;Murphy TL;Plessen KJ;Roessner V;Shin EY;Song DH;Song J;Tübing J;van den Ban E;Visscher F;Wanderer S;Woods M;Zinner SH;King RA;Tischfield JA;Heiman GA;Hoekstra PJ;Dietrich A
通讯作者：
Dietrich A