Endogenous adenosine restrains renin release in conscious rats.
Endogenous adenosine restrains renin release in conscious rats.
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内源性腺苷抑制清醒大鼠的肾素释放。
DOI：
10.1161/01.res.66.3.637
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发表时间：
1990
影响因子：
20.1
通讯作者：
Jackson,EK
中科院分区：
文献类型：
--
作者：
Kuan,CJ;Wells,JN;Jackson,EK
本研究的目的是检验内源性腺苷抑制肾素释放的药理学和病理生理刺激的功能的假设。为了实现这一目标，我们研究了腺苷受体拮抗剂，1，3-二丙基-8-（对磺苯基）黄嘌呤（DPSPX），急性肼苯哒嗪或慢性夹闭左肾动脉（肾血管性高血压大鼠）引起的肾素释放反应的影响。在清醒的，不受约束的大鼠，DPSPX显着增加血浆肾素活性（PRA）在对照组大鼠，肼苯哒嗪治疗的大鼠，肾血管性高血压大鼠。DPSPX对PRA的影响在肼苯哒嗪治疗的大鼠或肾血管性高血压大鼠中显著大于对照大鼠。DPSPX不影响任何组的动脉血压，不影响PRA的测量，也不改变循环中肾素活性的消除。在原位自动灌注肾中进行额外的实验，以便可以评估DPSPX对肾血流动力学和肾排泄功能的影响。在这个实验模型中，DPSPX还增加了肼苯哒嗪治疗的大鼠和肾血管性高血压大鼠的PRA，而不影响动脉压、肾血流量或钠排泄。在最后一组对清醒、不受约束大鼠的研究中，腺苷脱氨酶以剂量依赖性方式增加肼苯哒嗪处理大鼠的PRA，并显著增加PRA与肼苯哒嗪降压反应之间关系的斜率。我们得出结论：1）虽然肾脏具有A1和A2腺苷受体，分别介导对肾素释放的抑制和刺激作用，但内源性腺苷对肾素释放的主导作用是抑制性的。2)即使在基础生理条件下，内源性腺苷张力性抑制肾素释放。3)无论使用何种方法激活肾素释放，只要刺激肾素-血管紧张素系统，这种抑制作用就会增强。4)内源性腺苷通过直接作用于肾小球细胞负性调节肾素释放。
The purpose of this study was to test the hypothesis that endogenous adenosine functions to restrain the renin release response to pharmacological and pathophysiological stimuli. To achieve this objective, we examined the effects of an adenosine receptor antagonist, 1,3-dipropyl-8-(p-sulfophenyl)xanthine (DPSPX), on the renin release response induced by acute administration of hydralazine or by chronic clipping of the left renal artery (renovascular hypertensive rats). In conscious, unrestrained rats, DPSPX significantly increased plasma renin activity (PRA) in control rats, in rats treated with hydralazine, and in renovascular hypertensive rats. The effect of DPSPX on PRA was significantly greater in rats treated with hydralazine or in renovascular hypertensive rats compared with control rats. DPSPX did not influence arterial blood pressure in any group, did not affect the measurement of PRA, and did not alter the elimination of renin activity from the circulation. Additional experiments were performed in the in situ autoperfused kidney so that the effects of DPSPX on renal hemodynamics and renal excretory function could be assessed. In this experimental model, DPSPX also increased PRA in hydralazine-treated rats and in renovascular hypertensive rats without affecting arterial pressure, renal blood flow, or sodium excretion. In a final set of studies in conscious, unrestrained rats, adenosine deaminase increased PRA in a dose-dependent manner in hydralazine-treated rats and significantly increased the slope of the relation between PRA and the depressor response to hydralazine. We conclude: 1) Although the kidney has both A1 and A2 adenosine receptors mediating inhibitory and stimulatory actions, respectively, on renin release, the dominant effect of endogenous adenosine on renin release is inhibitory. 2) Even under basal physiological conditions, endogenous adenosine tonically inhibits renin release. 3) This inhibitory effect is augmented whenever the renin-angiotensin system is stimulated regardless of the approach used to activate renin release. 4) Endogenous adenosine negatively modulates renin release by a direct effect on juxtaglomerular cells.
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清醒大鼠中循环肾素的命运。
DOI：
10.1152/ajpendo.1987.252.1.e136
发表时间：
1987
期刊：
The American journal of physiology
影响因子：
--
作者：
S. Kim;H. Iwao;N. Nakamura;F. Ikemoto;K. Yamamoto
通讯作者：
K. Yamamoto
腺苷对大鼠心室自律性的抑制。
影响因子：
--
作者：
L. Heller;R. Olsson
通讯作者：
R. Olsson
茶碱对腺苷引起的肾素释放减少有拮抗作用。
DOI：
10.1152/ajprenal.1984.247.2.f246
发表时间：
1984
期刊：
The American journal of physiology
影响因子：
--
作者：
Spielman,WS
通讯作者：
Spielman,WS
通过放射免疫测定法测量高血压受试者血管紧张素 I 的循环水平。
DOI：
--
发表时间：
1979
期刊：
Journal of Laboratory and Clinical Medicine
影响因子：
--
作者：
R. Workman;C. Sussman;D. Burkitt;G. Liddle
通讯作者：
G. Liddle
肾血管和肾素分泌反应对腺苷受体激动剂的浓度依赖性。
DOI：
--
发表时间：
1985
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
Murray,RD;Churchill,PC
通讯作者：
Churchill,PC