Association between gestational PFAS exposure and Children's adiposity in a diverse population.
Association between gestational PFAS exposure and Children's adiposity in a diverse population.
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DOI：
10.1016/j.envres.2021.111820
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发表时间：
2022-01
影响因子：
8.3
通讯作者：
Hunt KJ
中科院分区：
文献类型：
--
作者：
Bloom MS;Commodore S;Ferguson PL;Neelon B;Pearce JL;Baumer A;Newman RB;Grobman W;Tita A;Roberts J;Skupski D;Palomares K;Nageotte M;Kannan K;Zhang C;Wapner R;Vena JE;Hunt KJ
全氟烷基物质（PFAS）是广泛分布的疑似肥胖原，可穿过胎盘。然而，很少有数据可用于评估PFAS暴露对不同人群中儿童肥胖的潜在胎儿影响。为了解决数据差距，我们估计了妊娠期PFAS浓度和儿童肥胖之间的关联，在一个不同的母亲-儿童队列。我们考虑了6 PFAS在孕早期血浆中，采用超高效液相色谱串联质谱法，收集非吸烟妇女低风险单胎妊娠（n=803）。确定4-8岁儿童的体重指数（BMI）、腰围（WC）、脂肪量、去脂量和%体脂作为肥胖的指标。我们估计了个体妊娠期PFAS与儿童肥胖和超重/肥胖的关系，并对混杂因素进行了调整。超重/肥胖的非西班牙裔黑人（31.7%）和西班牙裔（42.6%）儿童多于非西班牙裔白色（18.2%）和亚洲/太平洋岛民（16.4%）儿童（p<0.0001）。全氟辛烷磺酸（PFOS; 5.3纳克/毫升）和全氟辛酸（2.0纳克/毫升）在母体血液中的中位浓度最高。在没有肥胖的妇女中（n=667），更高的全氟十一烷酸（PFUnDA）与她们的孩子有更高的WC z评分相关（β=0.08，95%CI：0.01，0.14; p=0.02），脂肪量（β=0.55 kg，95%CI：0.21，0.90; p=0.002）和%体脂（β=0.01%; 95%CI：0.003，0.01; p=0.004），尽管PFUnDA与脂肪量的相关性在最高浓度下减弱。在没有肥胖的妇女中，PFAS与其子女肥胖的关联因自我报告的种族-民族而显着不同，尽管关联的方向不一致。相比之下，在肥胖妇女的子女中，全氟辛烷磺酸、全氟壬酸和全氟癸酸浓度越高，肥胖症越少（n=136）。我们的研究结果表明，特定的PFAS可能是发育性肥胖，而母亲的种族，种族可能是一个重要的修改器之间的协会妇女没有肥胖。
Perfluoroalkyl substances (PFAS) are widely distributed suspected obesogens that cross the placenta. However, few data are available to assess potential fetal effects of PFAS exposure on children’s adiposity in diverse populations. To address the data gap, we estimated associations between gestational PFAS concentrations and childhood adiposity in a diverse mother-child cohort. We considered 6 PFAS in first trimester blood plasma, measured using ultra-high-performance liquid chromatography with tandem mass spectrometry, collected from non-smoking women with low-risk singleton pregnancies (n=803). Body mass index (BMI), waist circumference (WC), fat mass, fat-free mass, and % body fat were ascertained in 4–8 year old children as measures of adiposity. We estimated associations of individual gestational PFAS with children’s adiposity and overweight/obesity, adjusted for confounders. There were more non-Hispanic Black (31.7%) and Hispanic (42.6%) children with overweight/obesity, than non-Hispanic white (18.2%) and Asian/Pacific Islander (16.4%) children (p<0.0001). Perfluorooctane sulfonate (PFOS; 5.3 ng/mL) and perfluorooctanoic acid (2.0 ng/mL) had the highest median concentrations in maternal blood. Among women without obesity (n=667), greater perfluoroundecanoic acid (PFUnDA) was associated with their children having higher WC z-score (β=0.08, 95%CI: 0.01, 0.14; p=0.02), fat mass (β=0.55 kg, 95%CI: 0.21, 0.90; p=0.002), and % body fat (β=0.01%; 95%CI: 0.003, 0.01; p=0.004), although the association of PFUnDA with fat mass attenuated at the highest concentrations. Among women without obesity, the associations of PFAS and their children’s adiposity varied significantly by self-reported race-ethnicity, although the direction of the associations was inconsistent. In contrast, among the children of women with obesity, greater, PFOS, perfluorononanoic acid, and perfluorodecanoic acid concentrations were associated with less adiposity (n=136). Our results suggest that specific PFAS may be developmental obesogens, and that maternal race-ethnicity may be an important modifier of the associations among women without obesity.
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影响因子：
6.9
作者：
Gordon-Larsen, Penny;The, Natalie S.;Adair, Linda S.
通讯作者：
Adair, Linda S.
DOI：
10.1016/j.jpeds.2009.04.051
发表时间：
2009-09-01
期刊：
The Journal of pediatrics
影响因子：
--
作者：
Cook, Stephen;Auinger, Peggy;Huang, Terry T-K
通讯作者：
Huang, Terry T-K
影响因子：
7.7
作者：
Cole, Stephen R.;Chu, Haitao;Schisterman, Enrique F.
通讯作者：
Schisterman, Enrique F.
影响因子：
7.7
作者：
Grewal, Jagteshwar;Grantz, Katherine L.;Louis, Germaine M. Buck
通讯作者：
Louis, Germaine M. Buck
影响因子：
8
作者：
Barlow, Sarah E.
通讯作者：
Barlow, Sarah E.