The Production of Porous Hydroxyapatite Scaffolds with Graded Porosity by Sequential Freeze-Casting.
The Production of Porous Hydroxyapatite Scaffolds with Graded Porosity by Sequential Freeze-Casting.
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DOI：
10.3390/ma10040367
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发表时间：
2017-03-31
期刊：
影响因子：
--
通讯作者：
Jung HD
中科院分区：
文献类型：
--
作者：
Lee H;Jang TS;Song J;Kim HE;Jung HD
采用顺序冷冻铸造法制备了具有孔隙度梯度结构的多孔羟基磷灰石（HA）支架。评价了多孔HA支架的孔结构、抗压强度和生物相容性。通过调节浇铸浆料中HA的初始含量来控制梯度HA支架内外层的孔隙率。致密部分与多孔部分之间的界面致密且紧密粘附。通过致密/多孔部分的相对厚度控制支架的孔隙率和压缩强度。此外，多孔HA支架在前成骨细胞附着和增殖方面显示出良好的生物相容性。结果表明，多孔羟基磷灰石支架具有承载部分作为骨移植在硬组织工程的潜力。
Porous hydroxyapatite (HA) scaffolds with porosity-graded structures were fabricated by sequential freeze-casting. The pore structures, compressive strengths, and biocompatibilities of the fabricated porous HA scaffolds were evaluated. The porosities of the inner and outer layers of the graded HA scaffolds were controlled by adjusting the initial HA contents of the casting slurries. The interface between the dense and porous parts was compact and tightly adherent. The porosity and compressive strengths of the scaffold were controlled by the relative thicknesses of the dense/porous parts. In addition, the porous HA scaffolds showed good biocompatibility in terms of preosteoblast cell attachment and proliferation. The results suggest that porous HA scaffolds with load-bearing parts have potential as bone grafts in hard-tissue engineering.
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影响因子：
3.9
作者：
Koh, Young-Hag;Lee, Eun-Jung;Kim, Hae-Won
通讯作者：
Kim, Hae-Won
影响因子：
14
作者：
Kim, HW;Lee, SY;Ko, JS
通讯作者：
Ko, JS
影响因子：
3
作者：
Jo, In-Hwan;Shin, Kwan-Ha;Kim, Hyoun-Ee
通讯作者：
Kim, Hyoun-Ee
影响因子：
3
作者：
Lee, Eun-Jung;Koh, Young-Hag;Kim, Hae-Won
通讯作者：
Kim, Hae-Won
影响因子：
2.4
作者：
GOLDSTEIN, SA
通讯作者：
GOLDSTEIN, SA