HIV/AIDS: epidemiology, pathophysiology, and treatment of Kaposi sarcoma-associated herpesvirus disease: Kaposi sarcoma, primary effusion lymphoma, and multicentric Castleman disease.
HIV/AIDS: epidemiology, pathophysiology, and treatment of Kaposi sarcoma-associated herpesvirus disease: Kaposi sarcoma, primary effusion lymphoma, and multicentric Castleman disease.
复制标题
DOI：
10.1086/592298
复制
发表时间：
2008-11-01
期刊：
影响因子：
--
通讯作者：
Dezube BJ
中科院分区：
文献类型：
--
作者：
Sullivan RJ;Pantanowitz L;Casper C;Stebbing J;Dezube BJ
KSHV感染与三种增殖性疾病的发展相关：卡波西肉瘤（KS），原发性渗出性淋巴瘤（PEL）和多中心Castleman病（MCD）。这些条件也与人类免疫缺陷病毒（HIV）感染密切相关，这两种病毒之间的重要协同相互作用已被描述。尽管每种情况下病毒基因表达模式存在差异，但KSHV编码类似的致癌蛋白，这些蛋白促进顺序和平行信号通路的激活。已经实施了针对这些独特信号通路的治疗策略，并且这种分子靶向是当前许多研究工作的焦点。本综述的范围是介绍KSHV的流行病学、病毒学和免疫学方面的当代知识，并重点介绍几种可能成为化疗靶点的关键癌基因产物。
KSHV infection is associated with the development of three proliferative diseases: Kaposi sarcoma (KS), primary effusion lymphoma (PEL), and multicentric Castleman disease (MCD). These conditions are also intimately associated with human immunodeficiency virus (HIV) infection, and important synergistic interactions between these two viruses have been described. Despite differences in viral gene expression patterns for each condition, KSHV encodes similar oncogenic proteins which promote the activation of sequential and parallel signaling pathways. Therapeutic strategies have been implemented to target these unique signaling pathways, and such molecular targeting is the focus of many current research efforts. The scope of this review is to present contemporary knowledge about the epidemiology, virology, and immunology of KSHV, as well as highlight several key oncogene products, which may be targets for chemotherapy.
登录
查看更多内容
影响因子：
3.7
作者：
Cotter, MA;Robertson, ES
通讯作者：
Robertson, ES
影响因子：
14.5
作者：
Chatlynne, LG;Ablashi, DV
通讯作者：
Ablashi, DV
影响因子：
64.8
作者：
ENSOLI, B;GENDELMAN, R;GALLO, RC
通讯作者：
GALLO, RC
影响因子：
4
作者：
Field, N;Low, W;Collins, M
通讯作者：
Collins, M
影响因子：
158.5
作者：
Cannon, MJ;Dollard, SC;Pellett, PE
通讯作者：
Pellett, PE