The influence of physical activity on risk of cardiovascular disease in people who are obese but metabolically healthy.
The influence of physical activity on risk of cardiovascular disease in people who are obese but metabolically healthy.
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DOI：
10.1371/journal.pone.0185127
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发表时间：
2017
期刊：
影响因子：
3.7
通讯作者：
Yoo HJ
中科院分区：
文献类型：
--
作者：
Moon S;Oh CM;Choi MK;Park YK;Chun S;Choi M;Yu JM;Yoo HJ
代谢健康肥胖（MHO）的代谢结果仍然存在争议。本研究的目的是确定身体活动对MHO的心血管疾病（CVD）结局的影响。这项研究包括了从韩国基因组和流行病学研究（KoGES）招募的参与者，这是一项基于人群的队列研究。排除了先前记录的心血管疾病或癌症，或在基线时接受过类固醇或抗凝剂的参与者。共有8144名参与者（3,942名男性和4,202名女性）符合入选标准。在校正年龄和性别的多变量考克斯回归模型中，与代谢健康的非肥胖（MHNO）患者相比，MHO患者的CVD风险并没有升高（HR，1.28; 95%CI，0.96-1.71），尽管非肥胖（HR，1.50; 95%CI，1.19-1.90）和肥胖（HR，1.85; 95%CI，1.48-2.30）代谢异常参与者的风险升高。然而，在按体力活动进行的亚组分析中，与活跃的MHNO参与者相比，不活跃的MHO参与者的CVD事件HR显著更高（HR，1.54; 95% CI，1.03-2.30），而活跃的MHO参与者的风险并未升高（HR，1.15; 95% CI，0.70-1.89）。与身体活动的MHNO参与者相比，身体活动的MHO参与者的CVD风险显着增加，而身体活动的MHO参与者则没有。
The metabolic outcomes of metabolically healthy obesity (MHO) remain controversial. The aim of the present study was to determine the effect of physical activity on the cardiovascular disease (CVD) outcomes of MHO. The study included participants who were followed for 10 years and recruited from the Korean Genome and Epidemiology Study (KoGES), a population-based cohort study. Participants with previously recorded CVDs or cancer, or who had received steroids or anticoagulants at baseline were excluded. A total of 8144 participants (3,942 men and 4,202 women) fulfilled inclusion criteria. In a multivariate Cox regression model adjusted for age and sex, MHO participants were not at elevated risk of CVD compared with their metabolically healthy non-obese (MHNO) counterparts (HR, 1.28; 95% CI, 0.96–1.71), although both the non-obese (HR, 1.50; 95% CI, 1.19–1.90) and obese (HR, 1.85; 95% CI, 1.48–2.30) participants with metabolic abnormalities were at elevated risk. However, in the subgroup analysis by physical activity, physically inactive MHO participants had a significantly higher HR for CVD events compared to active MHNO participants (HR, 1.54; 95% CI, 1.03–2.30), while active MHO participants were not at elevated risk (HR, 1.15; 95% CI, 0.70–1.89). Physically inactive MHO participants had significantly increased risk of CVD compared to physically active MHNO participants whereas physically active MHO participants did not.
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DOI：
10.1111/j.1749-6632.2012.06785.x
发表时间：
2013-01-01
期刊：
YEAR IN DIABETES AND OBESITY
影响因子：
--
作者：
Strasser, Barbara
通讯作者：
Strasser, Barbara
影响因子：
5.5
作者：
Tucker, Jared M.;Welk, Gregory J.;Beyler, Nicholas K.
通讯作者：
Beyler, Nicholas K.
DOI：
10.3803/enm.2014.29.4.427
发表时间：
2014-12-29
期刊：
Endocrinology and metabolism (Seoul, Korea)
影响因子：
--
作者：
Seo MH;Rhee EJ
通讯作者：
Rhee EJ
影响因子：
16.2
作者：
Choi SH;Kim TH;Lim S;Park KS;Jang HC;Cho NH
通讯作者：
Cho NH
影响因子：
29
作者：
Tran, Thien T.;Yamamoto, Yuji;Kahn, C. Ronald
通讯作者：
Kahn, C. Ronald