Altered functional connectivity of the primary visual cortex in subjects with amblyopia.
Altered functional connectivity of the primary visual cortex in subjects with amblyopia.
复制标题
弱视受试者初级视觉皮层功能连接的改变
DOI：
10.1155/2013/612086
复制
发表时间：
2013
影响因子：
3.1
通讯作者：
Jiang T
中科院分区：
文献类型：
--
作者：
Ding K;Liu Y;Yan X;Lin X;Jiang T
弱视通常发生在儿童早期并导致视力差或模糊，是一种视觉系统障碍，其特征在于在其他身体正常的眼睛中的缺陷或与眼睛的结构或功能异常不成比例的缺陷。我们先前的研究表明，屈光参差性弱视患者与视力正常的受试者相比，某些脑区的自发活动模式发生了改变。迄今为止，弱视患者的大脑视觉区（特别是主视觉区）的功能连接模式是否表现出特征性改变仍不清楚。在本研究中，我们调查了弱视和正常视力的个体之间的主要视觉区的功能连接的差异，使用静息功能磁共振成像。我们的研究结果表明，小脑和顶下小叶与弱视个体的主要视觉区的功能连接发生了改变，这一发现为弱视受试者的背侧视觉通路中断提供了进一步的证据。
Amblyopia, which usually occurs during early childhood and results in poor or blurred vision, is a disorder of the visual system that is characterized by a deficiency in an otherwise physically normal eye or by a deficiency that is out of proportion with the structural or functional abnormalities of the eye. Our previous study demonstrated alterations in the spontaneous activity patterns of some brain regions in individuals with anisometropic amblyopia compared to subjects with normal vision. To date, it remains unknown whether patients with amblyopia show characteristic alterations in the functional connectivity patterns in the visual areas of the brain, particularly the primary visual area. In the present study, we investigated the differences in the functional connectivity of the primary visual area between individuals with amblyopia and normal-sighted subjects using resting functional magnetic resonance imaging. Our findings demonstrated that the cerebellum and the inferior parietal lobule showed altered functional connectivity with the primary visual area in individuals with amblyopia, and this finding provides further evidence for the disruption of the dorsal visual pathway in amblyopic subjects.
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DOI：
10.1111/j.1460-9568.2009.06650.x
发表时间：
2009-03
期刊：
The European journal of neuroscience
影响因子：
--
作者：
Hess RF;Thompson B;Gole G;Mullen KT
通讯作者：
Mullen KT
影响因子：
3.7
作者：
Huxlin, KR;Pasternak, T
通讯作者：
Pasternak, T
影响因子：
5.7
作者：
Li, Xingfeng;Mullen, Kathy T.;Hess, Robert F.
通讯作者：
Hess, Robert F.
影响因子：
1.8
作者：
Aaen-Stockdale, Craig;Hess, Robert F.
通讯作者：
Hess, Robert F.
影响因子：
14.5
作者：
HASHIMOTO, M;OHTSUKA, K
通讯作者：
OHTSUKA, K