Neural processing correlates of assaultive violence exposure and PTSD symptoms during implicit threat processing: a network-level analysis among adolescent girls.
Neural processing correlates of assaultive violence exposure and PTSD symptoms during implicit threat processing: a network-level analysis among adolescent girls.
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DOI：
10.1016/j.pscychresns.2013.06.003
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发表时间：
2013-12-30
影响因子：
11.3
通讯作者：
Kilts CD
中科院分区：
文献类型：
--
作者：
Cisler JM;Scott Steele J;Smitherman S;Lenow JK;Kilts CD
儿童时期的攻击性暴力暴露是创伤后应激障碍（PTSD）的一个重要危险因素。本研究的目的是描述攻击和创伤后应激障碍的严重程度与情绪处理过程中确定的大规模网络组织的关系。年龄在12-16岁的青少年女孩（N=15）和没有（N=15）的攻击历史进行了功能磁共振成像，而从事的任务，提出了恐惧或中性的面部表情的图像。独立成分分析（伊卡）确定了一个frontocingulate网络，一个frontoparietal网络，和一个默认模式的网络。与中性面孔相比，攻击性暴露与恐惧的额扣带网络的显著更大激活相关。在额扣带回网络中，PTSD的严重程度与左杏仁核和膝周前扣带回之间的功能连接减弱有关。在额顶叶网络中，被侵犯的女孩表现出运动前皮层与右额中回的连接减弱。在默认模式网络中，攻击暴露和PTSD严重程度分别与内侧和外侧PFC的旁海马功能连接的加强相关。在被攻击组中，额扣带网络和额顶叶网络中功能连接的个体差异与被攻击组的家庭脱离密切相关。这些结果表明，攻击和PTSD症状之间的关联的功能组织的大规模额顶叶，额扣带，和默认模式网络在情绪处理。与非暴力等级的家庭脱离的关系表明家庭支持对攻击和PTSD症状的神经处理相关性的影响。
Assaultive violence exposure during childhood is a significant risk factor for posttraumatic stress disorder (PTSD). The purpose of the present study was to characterize the relationships of assault and PTSD severity with the organization of large-scale networks identified during emotion processing. Adolescent girls aged 12–16 with (N=15) and without (N=15) histories of assault underwent fMRI while engaged in a task that presented images of fearful or neutral facial expressions. Independent component analysis (ICA) identified a frontocingulate network, a frontoparietal network, and a default mode network. Assault exposure was associated with significantly greater activation of the frontocingulate network for fear versus neutral faces. Within the frontocingulate network, PTSD severity was associated with weakened functional connectivity between the left amygdala and the perigenual anterior cingulate. Within the frontoparietal network, assaulted girls demonstrated weakened connectivity of the premotor cortex with the right middle frontal gyrus. Within the default mode network, assault exposure and PTSD severity were associated with strengthening functional connectivity of the parahippocampus with the medial and lateral PFC, respectively. Individual differences in functional connections within the frontocingulate network and frontoparietal network among the assaulted group were strongly associated with caregiver-rated family disengagement. These results demonstrate associations between assault and PTSD symptoms on the functional organization of large-scale frontoparietal, frontocingulate, and default mode networks during emotion processing. The relationship with caregiver-rated family disengagement suggests the impact of family support on the neural processing correlates of assault and PTSD symptoms.
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