Dietary L-arginine supplementation protects weanling pigs from deoxynivalenol-induced toxicity.
Dietary L-arginine supplementation protects weanling pigs from deoxynivalenol-induced toxicity.
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日粮中添加 L-精氨酸可保护仔猪免受脱氧雪腐镰刀菌烯醇诱导的毒性
DOI：
10.3390/toxins7041341
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发表时间：
2015-04-15
期刊：
影响因子：
4.2
通讯作者：
Yin Y
中科院分区：
文献类型：
--
作者：
Wu L;Liao P;He L;Feng Z;Ren W;Yin J;Duan J;Li T;Yin Y
本研究旨在确定饲粮中添加L-精氨酸（Arg）对饲喂脱氧雪腐镰刀菌烯醇（DON）污染饲料的仔猪的积极影响。选用28日龄健康断奶仔猪18头，随机分为3组：对照组（对照组）、DON组（DON组）和DON +1%l-精氨酸组（DON + ARG组）。在补充Arg 21天后，DON和DON + ARG组中的仔猪通过饲喂6 mg/kg DON污染的饲料7天进行攻击。结果表明，DON对仔猪有一定的危害。而精氨酸组的空肠形态、血清、空肠和回肠中氨基酸含量均较对照组有明显改善（p < 0.05）。此外，DON组钠-葡萄糖转运蛋白-1（SGLT-1）、葡萄糖转运蛋白-2（GLUT-2）和y+ l-型氨基酸转运蛋白-1（y+LAT-1）的mRNA表达水平下调，而DON + ARG组则上调（p < 0.05）。总的来说，这些结果表明，饲料中补充精氨酸发挥保护作用，在猪饲养DON污染的饮食。
This study was conducted to determine the positive effects of dietary supplementation with l-arginine (Arg) on piglets fed a deoxynivalenol (DON)-contaminated diet. A total of eighteen, 28-day-old healthy weanling pigs were randomly assigned into one of three groups: uncontaminated basal diet (control group), 6 mg/kg DON-contaminated diet (DON group) and 6 mg/kg DON + 1% l-arginine (DON + ARG group). After 21 days of Arg supplementation, piglets in the DON and DON + ARG groups were challenged by feeding 6 mg/kg DON-contaminated diet for seven days. The results showed that DON resulted in damage to piglets. However, clinical parameters, including jejunal morphology, amino acid concentrations in the serum, jejunum and ileum, were improved by Arg (p < 0.05). Furthermore, the mRNA levels for sodium-glucose transporter-1 (SGLT-1), glucose transporter type-2 (GLUT-2) and y+l-type amino acid transporter-1 (y+LAT-1) were downregulated in the DON group, but the values were increased in the DON + ARG group (p < 0.05). Collectively, these results indicate that dietary supplementation with Arg exerts a protective role in pigs fed DON-contaminated diets.
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生长猪对日粮补充 L-精氨酸反应的代谢组学分析
影响因子：
3.5
作者：
He, Qinghua;Kong, Xiangfeng;Wu, Yongning
通讯作者：
Wu, Yongning
影响因子：
5.5
作者：
MURPHY, ME;BRAYDEN, JE
通讯作者：
BRAYDEN, JE
影响因子：
5.5
作者：
Mace, Oliver J.;Lister, Norma;Foley, David
通讯作者：
Foley, David
DOI：
10.3181/00379727-210-43947
发表时间：
1995-12-01
影响因子：
--
作者：
Meloche, JL;Smith, TK
通讯作者：
Smith, TK
日粮补充 L-精氨酸可增加生长肥育猪的肌肉增益并减少体脂量
影响因子：
3.5
作者：
Tan, Bie;Yin, Yulong;Wu, Guoyao
通讯作者：
Wu, Guoyao