Seasonal variation of serum KL-6 concentrations is greater in patients with hypersensitivity pneumonitis.
Seasonal variation of serum KL-6 concentrations is greater in patients with hypersensitivity pneumonitis.
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DOI：
10.1186/1471-2466-14-129
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发表时间：
2014-08-07
影响因子：
3.1
通讯作者：
Yokoyama A
中科院分区：
文献类型：
--
作者：
Ohnishi H;Miyamoto S;Kawase S;Kubota T;Yokoyama A
血清KL-6是诊断间质性肺疾病(ILD)的有用生物标志物。然而，KL-6还没有被用来区分不同类型的ILD。血清KL-6浓度可根据过敏性肺炎(HP)患者的抗原暴露水平而变化；然而，ILD患者血清KL-6浓度的季节性变化尚未确定。我们假设HP患者血清KL-6的季节性变化大于其他ILD患者。本研究的目的是确定不同类型ILD患者血清KL-6浓度的季节变化。对特发性肺纤维化(IPF，n = 16)、非特异性间质性肺炎(n = ，n = 16)、胶原血管病相关性间质性肺炎(CVD-IP，n = 33)、房屋相关性幽门螺杆菌(House-HP，n = 9)、鸟类相关性幽门螺杆菌(Bird-HP，n = 9)、肺纤维化合并肺气肿(CPFE，n CPFE 13)患者的血清KL-6浓度进行了回顾性分析。BIRD-HP和HOUSE-HP的血清KL-6的季节性变化大于其他ILD。Bird-HP冬季血清KL-6浓度显著升高，House-HP夏季血清KL-6浓度显著升高。急性HP组血清KL-6变化明显大于慢性HP组。受试者工作特征曲线分析表明，血清KL-6浓度较大的季节变化是Bird-HP的诊断依据。血清KL-6浓度季节性变化较大的ILD患者应考虑幽门螺杆菌感染。
Serum KL-6 is a useful biomarker for the diagnosis of interstitial lung diseases (ILD). However, KL-6 has not been used to discriminate different types of ILD. Serum KL-6 concentrations can vary depending on antigen exposure levels in patients with hypersensitivity pneumonitis (HP); however, seasonal changes in serum KL-6 concentrations in ILD have not been determined. We hypothesized that seasonal variation of serum KL-6 is greater in HP than for the other ILD. The aim of this study was to determine seasonal variation of serum KL-6 concentrations in various ILD. Serum KL-6 concentrations in the summer season from June 1 to September 30 and the winter season from November 1 to February 28 were retrospectively analyzed in patients with idiopathic pulmonary fibrosis (IPF, n = 16), non-specific interstitial pneumonia (NSIP, n = 16), collagen vascular disease-associated interstitial pneumonia (CVD-IP, n = 33), house-related HP (House-HP, n = 9), bird-related HP (Bird-HP, n = 9), and combined pulmonary fibrosis and emphysema (CPFE, n = 13). Bird-HP and House-HP showed greater seasonal serum KL-6 variation than the other ILD. Serum KL-6 concentrations in Bird-HP were significantly increased in the winter and KL-6 concentrations in House-HP were significantly increased in the summer. Serum KL-6 variation was significantly greater in acute HP than chronic HP. Receiver operating characteristic curve analysis revealed that greater seasonal variation in serum KL-6 concentrations is diagnostic for Bird-HP. HP should be considered in ILD with greater seasonal changes in serum KL-6 concentrations.
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影响因子：
9.6
作者：
KOHNO, N;KYOIZUMI, S;AKIYAMA, M
通讯作者：
AKIYAMA, M
影响因子：
5.9
作者：
Ohtani, Y;Saiki, S;Yoshizawa, Y
通讯作者：
Yoshizawa, Y
影响因子：
1.8
作者：
Linssen, KCFM;Jacobs, JA;Drent, M
通讯作者：
Drent, M
影响因子：
76.2
作者：
Morell, Ferran;Villar, Ana;Raghu, Ganesh
通讯作者：
Raghu, Ganesh
影响因子：
10
作者：
Ohnishi, H;Yokoyama, A;Kohno, N
通讯作者：
Kohno, N