Linking gut microbiota, metabolic syndrome and economic status based on a population-level analysis.
Linking gut microbiota, metabolic syndrome and economic status based on a population-level analysis.
复制标题
基于人群水平分析将肠道微生物群、代谢综合征和经济状况联系起来
DOI：
10.1186/s40168-018-0557-6
复制
发表时间：
2018-09-24
期刊：
影响因子：
15.5
通讯作者：
Zhou HW
中科院分区：
文献类型：
--
作者：
He Y;Wu W;Wu S;Zheng HM;Li P;Sheng HF;Chen MX;Chen ZH;Ji GY;Zheng ZD;Mujagond P;Chen XJ;Rong ZH;Chen P;Lyu LY;Wang X;Xu JB;Wu CB;Yu N;Xu YJ;Yin J;Raes J;Ma WJ;Zhou HW
代谢综合征(METS)流行与经济发展、生活方式转变和肠道微生物区系失调有关，但在人口规模上对这些关系的研究很少。在这里，我们利用广东省肠道微生物组计划(GGMP)，这是东部最大的基于人群的肠道微生物组数据集，涵盖不同经济地位的个人，调查肠道微生物组与宿主生理、饮食、地理、体力活动和社会经济地位的关系。结果在人口水平上，529个OTU与METS显著相关。变形杆菌和变形杆菌(瘤胃球菌科除外)的OTU主要与甲硫氨酸呈正相关，而拟杆菌和瘤胃球菌科的OTU与甲硫氨酸呈负相关。214个OTU与宿主经济地位显著相关(140个积极关联和74个负面关联)，其中157个OTU也与METs相关。制定了一种微生物蛋氨酸指数来代表蛋氨酸的整体肠道生态失调。无论他们的经济状况或地理位置如何，METS受试者的这一指数都显着较高。这些指数值并没有随着个人经济地位的增加而增加，尽管在经济地位较高的人中，METS的患病率明显更高。随着经济地位的提高，研究人群倾向于消费更多的水果和蔬菜，更少的谷物，而肉类消费没有变化。久坐时间与较高的经济地位显著正相关。Mets指数与久坐不动的生活方式存在相加效应，高Mets指数值和不良生活方式个体的Mets患病率显著高于其他人群。结论肠道微生物群与Mets和经济状况有关。随着经济的发展，长期久坐的生活方式，而不是西方化的饮食模式，是我们东方人口最显著的生活方式变化。此外，肠道生态失调和西方人的生活方式对甲亢症患病率的增加具有相加作用。
BackgroundThe metabolic syndrome (MetS) epidemic is associated with economic development, lifestyle transition and dysbiosis of gut microbiota, but these associations are rarely studied at the population scale. Here, we utilised the Guangdong Gut Microbiome Project (GGMP), the largest Eastern population-based gut microbiome dataset covering individuals with different economic statuses, to investigate the relationships between the gut microbiome and host physiology, diet, geography, physical activity and socioeconomic status.ResultsAt the population level, 529 OTUs were significantly associated with MetS. OTUs from Proteobacteria and Firmicutes (other than Ruminococcaceae) were mainly positively associated with MetS, whereas those from Bacteroidetes and Ruminococcaceae were negatively associated with MetS. Two hundred fourteen OTUs were significantly associated with host economic status (140 positive and 74 negative associations), and 157 of these OTUs were also MetS associated. A microbial MetS index was formulated to represent the overall gut dysbiosis of MetS. The values of this index were significantly higher in MetS subjects regardless of their economic status or geographical location. The index values did not increase with increasing personal economic status, although the prevalence of MetS was significantly higher in people of higher economic status. With increased economic status, the study population tended to consume more fruits and vegetables and fewer grains, whereas meat consumption was unchanged. Sedentary time was significantly and positively associated with higher economic status. The MetS index showed an additive effect with sedentary lifestyle, as the prevalence of MetS in individuals with high MetS index values and unhealthy lifestyles was significantly higher than that in the rest of the population.ConclusionsThe gut microbiome is associated with MetS and economic status. A prolonged sedentary lifestyle, rather than Westernised dietary patterns, was the most notable lifestyle change in our Eastern population along with economic development. Moreover, gut dysbiosis and a Western lifestyle had an additive effect on increasing MetS prevalence.
登录
查看更多内容
肠道菌群通过短链脂肪酸受体GPR43抑制胰岛素介导的脂肪积累。
影响因子：
16.6
作者：
通讯作者：
--
影响因子：
3.7
作者：
Armougom F;Henry M;Vialettes B;Raccah D;Raoult D
通讯作者：
Raoult D
影响因子：
29.4
作者：
Bouter, Kristien E.;van Raalte, Daniel H.;Nieuwdorp, Max
通讯作者：
Nieuwdorp, Max
DOI：
10.1038/ismej.2012.153
发表时间：
2013-04
期刊：
The ISME journal
影响因子：
--
作者：
通讯作者：
--
影响因子：
56.9
作者：
Falony, Gwen;Joossens, Marie;Raes, Jeroen
通讯作者：
Raes, Jeroen