Critical role of neuropeptides B/W receptor 1 signaling in social behavior and fear memory.
Critical role of neuropeptides B/W receptor 1 signaling in social behavior and fear memory.
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DOI：
10.1371/journal.pone.0016972
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发表时间：
2011-02-24
期刊：
影响因子：
3.7
通讯作者：
Sakurai T
中科院分区：
文献类型：
--
作者：
Nagata-Kuroiwa R;Furutani N;Hara J;Hondo M;Ishii M;Abe T;Mieda M;Tsujino N;Motoike T;Yanagawa Y;Kuwaki T;Yamamoto M;Yanagisawa M;Sakurai T
神经肽B/W受体1（NPBWR 1）是一种G蛋白偶联受体，最初被报道为孤儿受体，其配体在2002年和2003年由本研究组和其他研究组鉴定。为了研究NPBWR 1的生理作用，我们研究了Npbwr 1 −/−小鼠的表型。与野生型小鼠相比，当遇到入侵小鼠时，Npbwr 1 −/−小鼠表现出与陌生小鼠的冲动接触，产生更强烈的接近它们的行为，并且有更长的接触和追逐时间沿着更大和持续的心率和血压升高。Npbwr 1 −/−小鼠对身体应激的自主神经和神经内分泌反应也有所增加，这表明NPBWR 1的损伤导致应激脆弱性。我们还观察到这些小鼠在情境恐惧条件化测试中表现出异常。这些数据表明，NPBWR 1在边缘系统功能和应激反应中起着关键作用。组织学和电生理学研究表明，NPBWR 1作为一个抑制性调节剂的GABA能神经元的一个亚群在外侧分裂的CeA和终止应激反应。这些发现表明NPBWR 1在调节杏仁核功能的重要作用，在身体和社会压力。
Neuropeptide B/W receptor 1 (NPBWR1) is a G-protein coupled receptor, which was initially reported as an orphan receptor, and whose ligands were identified by this and other groups in 2002 and 2003. To examine the physiological roles of NPBWR1, we examined phenotype of Npbwr1 −/− mice. When presented with an intruder mouse, Npbwr1 −/− mice showed impulsive contact with the strange mice, produced more intense approaches toward them, and had longer contact and chasing time along with greater and sustained elevation of heart rate and blood pressure compared to wild type mice. Npbwr1 −/− mice also showed increased autonomic and neuroendocrine responses to physical stress, suggesting that impairment of NPBWR1 leads to stress vulnerability. We also observed that these mice show abnormality in the contextual fear conditioning test. These data suggest that NPBWR1 plays a critical role in limbic system function and stress responses. Histological and electrophysiological studies showed that NPBWR1 acts as an inhibitory regulator on a subpopulation of GABAergic neurons in the lateral division of the CeA and terminates stress responses. These findings suggest important roles of NPBWR1 in regulating amygdala function during physical and social stress.
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影响因子：
2.7
作者：
Ramos, A;Berton, O;Chaouloff, F
通讯作者：
Chaouloff, F
影响因子：
64.8
作者：
Ciocchi, Stephane;Herry, Cyril;Luethi, Andreas
通讯作者：
Luethi, Andreas
影响因子：
64.5
作者：
Shumyatsky, GP;Tsvetkov, E;Bolshakov, VY
通讯作者：
Bolshakov, VY
DOI：
10.1073/pnas.0837789100
发表时间：
2003-05-13
影响因子：
11.1
作者：
Tanaka, H;Yoshida, T;Yanagisawa, M
通讯作者：
Yanagisawa, M
影响因子：
4.4
作者：
ODOWD, BF;SCHEIDELER, MA;GEORGE, SR
通讯作者：
GEORGE, SR