Inside the mucosal immune system.
Inside the mucosal immune system.
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DOI：
10.1371/journal.pbio.1001397
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发表时间：
2012
期刊：
影响因子：
9.8
通讯作者：
Fujihashi K
中科院分区：
文献类型：
--
作者：
McGhee JR;Fujihashi K
先天和免疫细胞及其衍生介质的复杂网络共同发挥作用，以保护我们免受环境中遇到的有毒元素和传染性微生物疾病的侵害。这个庞大的网络通过使用例如胃肠道（GI）和上呼吸道（UR）中的单细胞上皮有效地运作，并通过保护其完整性的相邻细胞和淋巴组织加强。扰动肯定会发生，有时会导致炎性疾病或感染，这些疾病或感染可能会使人衰弱并危及生命。例如，眼睛，皮肤，鼻子和UR或消化道的过敏是常见的。同样，遗传背景和环境微生物的遭遇可能导致炎症性肠病（IBD）。这种粘膜免疫系统（MIS）在健康和疾病中的作用目前正在全世界范围内由具有不同专业知识和兴趣的科学家进行深入研究。尽管开展了这项活动，但仍存在许多问题需要详细解答，以便充分利用MIS。在本期PLOS Biology中，一篇研究文章描述了一种多尺度体内系统方法，以精确确定肠道上皮细胞如何对静脉注射途径给予的炎症细胞因子肿瘤坏死因子-α（TNF-α）作出反应。这篇文章揭示了一个以前未知的途径，其中几种细胞类型和它们分泌的介质协调工作，以防止小鼠小肠上皮细胞死亡。这项有趣的研究结果说明了体内系统生物学方法如何用于解开用于保护宿主免受环境影响的复杂机制。
An intricate network of innate and immune cells and their derived mediators function in unison to protect us from toxic elements and infectious microbial diseases that are encountered in our environment. This vast network operates efficiently by use of a single cell epithelium in, for example, the gastrointestinal (GI) and upper respiratory (UR) tracts, fortified by adjoining cells and lymphoid tissues that protect its integrity. Perturbations certainly occur, sometimes resulting in inflammatory diseases or infections that can be debilitating and life threatening. For example, allergies in the eyes, skin, nose, and the UR or digestive tracts are common. Likewise, genetic background and environmental microbial encounters can lead to inflammatory bowel diseases (IBDs). This mucosal immune system (MIS) in both health and disease is currently under intense investigation worldwide by scientists with diverse expertise and interests. Despite this activity, there are numerous questions remaining that will require detailed answers in order to use the MIS to our advantage. In this issue of PLOS Biology, a research article describes a multi-scale in vivo systems approach to determine precisely how the gut epithelium responds to an inflammatory cytokine, tumor necrosis factor-alpha (TNF-α), given by the intravenous route. This article reveals a previously unknown pathway in which several cell types and their secreted mediators work in unison to prevent epithelial cell death in the mouse small intestine. The results of this interesting study illustrate how in vivo systems biology approaches can be used to unravel the complex mechanisms used to protect the host from its environment.
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DOI：
10.1084/jem.20011502
发表时间：
2002-01-07
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Campbell DJ;Butcher EC
通讯作者：
Butcher EC
影响因子：
8.7
作者：
Schröfelbauer B;Hoffmann A
通讯作者：
Hoffmann A
影响因子：
7.3
作者：
Lau KS;Juchheim AM;Cavaliere KR;Philips SR;Lauffenburger DA;Haigis KM
通讯作者：
Haigis KM
影响因子：
30.5
作者：
通讯作者：
--
影响因子：
29.7
作者：
Reizis B;Bunin A;Ghosh HS;Lewis KL;Sisirak V
通讯作者：
Sisirak V