Prions are a common mechanism for phenotypic inheritance in wild yeasts.
Prions are a common mechanism for phenotypic inheritance in wild yeasts.
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DOI：
10.1038/nature10875
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发表时间：
2012-02-15
期刊：
影响因子：
64.8
通讯作者：
Lindquist, Susan
中科院分区：
文献类型：
--
作者：
Halfmann, Randal;Jarosz, Daniel F.;Jones, Sandra K.;Chang, Amelia;Lancaster, Alex K.;Lindquist, Susan
酵母朊病毒蛋白的自我模板构象作为遗传的表观遗传因素。酵母朊病毒可能提供了一种产生遗传表型多样性的机制，这种多样性促进了在波动环境中的生存和新性状的进化。然而，这一假设极具争议。在野生菌株中没有发现创造新性状的朊病毒，这导致人们认为它们是实验室培养的罕见“疾病”。在这里，我们对约700株野生酵母菌株进行了[PSI+]或[MOT3+]的生物化学测试，并在许多菌株中发现了这些朊病毒。它们赋予了在选择性条件下经常有益的不同表型。简单的减数分裂重组的变异窝藏在一个菌株很容易固定一个这样的性状，使其强大和朊病毒的独立。最后，我们对未知的朊病毒成分进行了基因筛选。整整三分之一的野生菌株携带有它们。这些，也创造了多样的，往往是有益的表型。因此，朊病毒在自然界中广泛地控制着可遗传的性状，其方式可以极大地扩大适应性机会。
The self-templating conformations of yeast prion proteins act as epigenetic elements of inheritance. Yeast prions might provide a mechanism for generating heritable phenotypic diversity that promotes survival in fluctuating environments and the evolution of new traits. However, this hypothesis is highly controversial. Prions that create new traits have not been found in wild strains, leading to the perception that they are rare “diseases” of laboratory cultivation. Here we biochemically test ~700 wild strains of Saccharomyces for [PSI+] or [MOT3+], and find these prions in many. They conferred diverse phenotypes that were frequently beneficial under selective conditions. Simple meiotic re-assortment of the variation harboured within a strain readily fixed one such trait, making it robust and prion-independent. Finally, we genetically screened for unknown prion elements. Fully one third of wild strains harboured them. These, too, created diverse, often beneficial phenotypes. Thus, prions broadly govern heritable traits in nature, in a manner that could profoundly expand adaptive opportunities.
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影响因子：
3.7
作者：
Diezmann S;Dietrich FS
通讯作者：
Dietrich FS
使用下一代 DNA 测序数据进行变异发现和基因分型的框架。
影响因子：
30.8
作者：
通讯作者：
--
影响因子：
19
作者：
Halfmann, Randal;Alberti, Simon;Lindquist, Susan
通讯作者：
Lindquist, Susan
DOI：
10.1073/pnas.0906183107
发表时间：
2010-01-26
影响因子：
11.1
作者：
Feinberg, Andrew P.;Irizarry, Rafael A.
通讯作者：
Irizarry, Rafael A.
影响因子：
56.9
作者：
CHERNOFF, YO;LINDQUIST, SL;LIEBMAN, SW
通讯作者：
LIEBMAN, SW