Self-administered cocaine causes long-lasting increases in impulsive choice in a delay discounting task.
Self-administered cocaine causes long-lasting increases in impulsive choice in a delay discounting task.
复制标题
DOI：
10.1037/a0020458
复制
发表时间：
2010-08
影响因子：
1.9
通讯作者：
Setlow, Barry
中科院分区：
文献类型：
--
作者：
Mendez, Ian A.;Simon, Nicholas W.;Hart, Nigel;Mitchell, Marci R.;Nation, Jack R.;Wellman, Paul J.;Setlow, Barry
可卡因的使用与高水平的冲动选择（对即时奖励的偏好超过延迟奖励）有关，但尚不清楚可卡因的使用是否会导致冲动选择的增加，或者冲动选择的增加是否只是可卡因使用的诱发因素。本研究探讨了先前的可卡因自我管理大鼠执行延迟折扣任务，通常用于衡量冲动的选择的影响。将静脉内导管植入雄性Long-Evans大鼠，并在恢复后，训练其自我施用30 mg/kg/天可卡因HCl（约10 mg/kg/天）。0.5 mg/kg/输注）连续14天（对照组接受静脉内盐水输注）。停药三周后，所有大鼠均限食，并开始在标准操作室中进行延迟折扣任务训练。在每一次试验中，老鼠都要在两个杠杆中做出选择。按下一个杠杆立即提供一个小的食物奖励，按下另一个杠杆在可变的延迟时间后提供一个大的食物奖励。与对照组相比，自我给予可卡因的大鼠表现出更大的冲动选择（对小的立即奖励的偏好增强，反映在较短的无差异点上），但与“概率折扣”任务的对照组没有什么不同，在该任务中，他们在小的确定性和大的不确定性奖励之间进行选择。这些数据表明，自我管理的可卡因可以导致持久的冲动选择，并在人类可卡因用户中观察到的高水平的冲动选择可能部分是由于可卡因对大脑功能的长期影响。
Cocaine use is associated with high levels of impulsive choice (preference for immediate over delayed rewards), but it is not clear whether cocaine use causes elevated impulsive choice, or whether elevated impulsive choice is solely a predisposing factor for cocaine use. This study examined the effects of prior cocaine self-administration on rats performing a delay discounting task commonly used to measure impulsive choice. Male Long-Evans rats were implanted with intravenous catheters, and following recovery, were trained to self-administer 30 mg/kg/day cocaine HCl (approx. 0.5 mg/kg/infusion) for 14 consecutive days (a control group received yoked intravenous saline infusions). Following three weeks of withdrawal, all rats were food-restricted and began training on the delay discounting task in standard operant chambers. On each trial, rats were given a choice between two levers. A press on one lever delivered a small food reward immediately, and a press on the other delivered a large food reward after a variable delay period. Rats that self-administered cocaine displayed greater impulsive choice (enhanced preference for the small immediate over the large delayed reward, as reflected by shorter indifference points) compared to controls, but were no different from controls on a “probabilistic discounting” task in which they chose between small certain and large uncertain rewards. These data suggest that self-administered cocaine can cause lasting elevations in impulsive choice, and that the high levels of impulsive choice observed in human cocaine users may be due in part to long-term effects of cocaine on brain function.
登录
查看更多内容
影响因子：
3.4
作者：
Gipson, Cassandra D.;Bardo, Michael T.
通讯作者：
Bardo, Michael T.
影响因子：
10.6
作者：
Diergaarde, Leontien;Pattij, Tommy;De Vries, Taco J.
通讯作者：
De Vries, Taco J.
影响因子：
17.7
作者：
Kalivas, PW;Volkow, ND
通讯作者：
Volkow, ND
影响因子：
3.6
作者：
Anker, Justin J.;Perry, Jennifer L.;Gliddon, Luke A.;Carroll, Marilyn E.
通讯作者：
Carroll, Marilyn E.
影响因子：
4.4
作者：
Heil, Sarah H.;Johnson, Matthew W.;Bickel, Warren K.
通讯作者：
Bickel, Warren K.