Impulsivity predicts the escalation of cocaine self-administration in rats.
Impulsivity predicts the escalation of cocaine self-administration in rats.
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DOI：
10.1016/j.pbb.2009.05.013
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发表时间：
2009-09
影响因子：
3.6
通讯作者：
Carroll, Marilyn E.
中科院分区：
文献类型：
--
作者：
Anker, Justin J.;Perry, Jennifer L.;Gliddon, Luke A.;Carroll, Marilyn E.
冲动，作为衡量的延迟折扣任务，预测收购可卡因自我管理和恢复可卡因寻求大鼠。本研究的目的是将这些结果扩展到药物自我给药的递增阶段。雌性大鼠最初筛选高（HiI）或低（LOI）的冲动性食物强化使用延迟折扣程序。然后，他们被植入静脉导管，并接受培训，以杠杆按压可卡因输注（0.8 mg/kg）。一旦可卡因摄入量稳定，在3、2小时的短期接触期间，允许大鼠在固定比率1（FR 1）时间表下自我施用可卡因（0.4 mg/kg）。随后，根据递增比例（PR）计划对3种剂量的可卡因（0.2、0.8和3.2 mg/kg）进行了简要评估。PR测试后，可卡因剂量改为0.4 mg/kg。然后将疗程延长至6小时，持续21天（延长使用时间），并根据FR 1时间表提供0.4 mg/kg可卡因。在21天的延长使用期后，重新评估了短期使用和PR剂量-反应条件下的缓解和输注。结果表明，HiI大鼠在扩展访问条件下可卡因强化反应升级，但LoI大鼠没有。HiI大鼠在升级后短通路条件下也获得了比LoI大鼠显著更多的输注。然而，HiI和LoI大鼠在延长入路PR前和延长入路PR后的条件下没有差异。这项研究表明，冲动的个体差异预测升级的可卡因自我管理的雌性大鼠，这可能有影响，在女性的可卡因摄入量的狂欢样模式的预测。
Impulsivity, as measured by the delay-discounting task, predicts the acquisition of cocaine self-administration and reinstatement of cocaine seeking in rats. The purpose of this study was to extend these results to the escalation phase of drug self-administration. Female rats were initially screened for high (HiI) or low (LoI) impulsivity for food reinforcement using a delay-discounting procedure. They were then implanted with i.v. catheters and trained to lever press for cocaine infusions (0.8 mg/kg). Once cocaine intake stabilized, rats were allowed to self-administer cocaine (0.4 mg/kg) under a fixed-ratio 1 (FR 1) schedule during 3, 2 hr short-access sessions. Subsequently, performance was briefly assessed under a progressive ratio (PR) schedule for 3 doses of cocaine (0.2, 0.8, and 3.2 mg/kg). Following PR testing, the cocaine dose was then changed to 0.4 mg/kg. Session length was then extended to 6-hr for 21 days (extended access), and 0.4 mg/kg cocaine was available under a FR 1 schedule. After the 21-day extended access phase, responses and infusions under the short access and PR dose-response conditions were reassessed. The results indicated that HiI rats escalated cocaine-reinforced responding during the extended access condition, but LoI rats did not. HiI rats also earned significantly more infusions than LoI rats under the post-escalation short-access condition. However, HiI and LoI rats did not differ under the pre- and post-extended access PR conditions. This study suggests that individual differences in impulsivity predict escalation of cocaine self-administration in female rats, which may have implications in the prediction of binge-like patterns of cocaine intake in women.
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影响因子：
10.6
作者：
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通讯作者：
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通讯作者：
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