Complement Dependent Synaptic Reorganisation During Critical Periods of Brain Development and Risk for Psychiatric Disorder.
Complement Dependent Synaptic Reorganisation During Critical Periods of Brain Development and Risk for Psychiatric Disorder.
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DOI：
10.3389/fnins.2022.840266
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发表时间：
2022
影响因子：
4.3
通讯作者：
Wilkinson, Lawrence S.
中科院分区：
文献类型：
--
作者：
Westacott, Laura J.;Wilkinson, Lawrence S.
关键词：
我们现在知道，免疫系统在整个生命周期内大脑发育的复杂过程中发挥着重要作用，在没有病理性炎症或感染的情况下，在生理条件下执行一些重要的体内平衡功能。特别是，在生命早期的关键时期，补体介导的突触修剪可能在塑造大脑发育和随后的精神病理学风险方面发挥关键作用，包括精神分裂症和自闭症谱系障碍等神经发育障碍。然而，这些疾病在发病、病程和性别之间的患病率差异很大，这表明免疫系统、性别和不同大脑功能基础电路的独特发展轨迹之间的复杂相互作用尚不完全清楚。在区域回路成熟的不同关键时期，动态平衡神经免疫相互作用的扰动可能会对精神疾病的表型产生过多的长期影响，但目前我们对这些机制如何影响大脑不同发育阶段的结构和功能变化的理解存在差距。在这篇文章中，我们将考虑补体介导的突触修剪领域的最新发展，其中我们的理解开始超越最初描述这一过程的视觉系统，转向与精神疾病潜在相关的大脑区域和发育时期。
We now know that the immune system plays a major role in the complex processes underlying brain development throughout the lifespan, carrying out a number of important homeostatic functions under physiological conditions in the absence of pathological inflammation or infection. In particular, complement-mediated synaptic pruning during critical periods of early life may play a key role in shaping brain development and subsequent risk for psychopathology, including neurodevelopmental disorders such as schizophrenia and autism spectrum disorders. However, these disorders vary greatly in their onset, disease course, and prevalence amongst sexes suggesting complex interactions between the immune system, sex and the unique developmental trajectories of circuitries underlying different brain functions which are yet to be fully understood. Perturbations of homeostatic neuroimmune interactions during different critical periods in which regional circuits mature may have a plethora of long-term consequences for psychiatric phenotypes, but at present there is a gap in our understanding of how these mechanisms may impact on the structural and functional changes occurring in the brain at different developmental stages. In this article we will consider the latest developments in the field of complement mediated synaptic pruning where our understanding is beginning to move beyond the visual system where this process was first described, to brain areas and developmental periods of potential relevance to psychiatric disorders.
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DOI：
10.1002/cne.22359
发表时间：
2010-07-15
期刊：
The Journal of comparative neurology
影响因子：
--
作者：
Cressman VL;Balaban J;Steinfeld S;Shemyakin A;Graham P;Parisot N;Moore H
通讯作者：
Moore H
影响因子：
25
作者：
Cong, Qifei;Soteros, Breeanne M.;Sia, Gek-Ming
通讯作者：
Sia, Gek-Ming
影响因子：
7.2
作者：
Chung WS;Allen NJ;Eroglu C
通讯作者：
Eroglu C
影响因子：
5.3
作者：
Bjartmar, Lisa;Huberman, Andrew D.;Perin, Mark S.
通讯作者：
Perin, Mark S.
影响因子：
11.1
作者：
Crapser, Joshua D.;Spangenberg, Elizabeth E.;Green, Kim N.
通讯作者：
Green, Kim N.