Prefrontal cortical inputs to the basal amygdala undergo pruning during late adolescence in the rat.
Prefrontal cortical inputs to the basal amygdala undergo pruning during late adolescence in the rat.
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DOI：
10.1002/cne.22359
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发表时间：
2010-07-15
期刊：
影响因子：
--
通讯作者：
Moore H
中科院分区：
文献类型：
--
作者：
Cressman VL;Balaban J;Steinfeld S;Shemyakin A;Graham P;Parisot N;Moore H
情感和社会行为的转变，其中许多涉及杏仁核回路，是许多哺乳动物物种青春期的特征。在这项研究中，我们使用大鼠作为一个模型，我们提供了第一个证据，即杏仁基底核(BA)的传入在青春期经历显著的结构重建。我们使用定量追踪和基因表达谱方法来表征大鼠不同年龄的BA的内侧前额叶皮质(MPFC)输入的变化，这些年龄类似于大鼠的幼年期晚期[出生后25天(P)]、青春期晚期(P45)和成年(P90)。根据荧光金沉积后的评估，在mPFC内BA投射神经元的数量在P25到P45之间保持稳定，但在P45到P90之间减少了约50%。以生物素右旋糖胺沉积为中心的顺行追踪显示，在此期间，基底核内mPFC来源的轴突终末的密度也显著降低，这种影响在基底外侧背核尤为明显。在BA内，突起或突触可塑性的基因表达也发生了非常显著的变化，最显著的是在RAS/GTP酶超家族中，以及在调节细胞骨架动力学和类固醇合成/脂代谢的途径中。这些数据提供了一致的证据，表明mPFC对BA的输入在青春期晚期或成年期早期被修剪。此外，这些传入神经元的结构重塑可能伴随着BA内轴突可塑性的显著变化。
Transformations in affective and social behaviors, many of which involve amygdalar circuits, are hallmarks of adolescence in many mammalian species. In this study, using the rat as a model, we provide the first evidence that afferents of the basal amygdala (BA) undergo significant structural remodeling during adolescence. We used quantitative tract-tracing and gene expression profiling methods to characterize changes in the medial prefrontal cortical (mPFC) inputs to the BA across ages analogous to the late juvenile period [postnatal day (P) 25], late adolescence (P45), and adulthood (P90) in the rat. As assessed after deposition of Fluorogold into the BA, the number of BA-projecting neurons in the mPFC remained stable between P25 and P45 but decreased by about 50% between P45 and P90. Anterograde tract tracing with biotin dextran amine deposits centered in the ventral prelimbic cortex revealed that, during this period, the density of mPFC-derived axon terminals in the BA also decrease significantly, an effect particularly evident in the dorsal basolateral nucleus. Within the BA, there were also highly significant changes in gene expression indicative of neurite or synaptic plasticity, most notably in the Ras/GTPase superfamily, and in pathways that regulate cytoskeletal dynamics and steroid synthesis/lipid metabolism. These data provide convergent evidence that mPFC inputs to the BA are pruned during late adolescence or early adulthood. Moreover, the structural remodeling within these afferents may be accompanied by significant changes in neurite plasticity within the BA.
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影响因子：
5.7
作者：
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发表时间：
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