Expression of nerve growth factor receptor in paraffin-embedded soft tissue tumors.
Expression of nerve growth factor receptor in paraffin-embedded soft tissue tumors.
复制标题
石蜡包埋软组织肿瘤中神经生长因子受体的表达。
DOI：
--
复制
发表时间：
1988
影响因子：
6
通讯作者：
J. Brooks
中科院分区：
文献类型：
--
作者：
P. Perosio;J. Brooks
间叶肿瘤中生长因子和受体的鉴定可能对理解肉瘤的生长调节至关重要。在对人软组织肿瘤（STT）中生长因子和受体表达的免疫组化研究中，仅发现1种抗血清能够在石蜡包埋组织中起作用。对141例STT进行了详细的研究，以确定神经生长因子受体（NGF-R）的表达频率，其对神经肿瘤的特异性和敏感性，以及固定对检测的影响。在正常间质组织中，仅可见神经鞘和血管周围染色。在横纹肌肉瘤、血管肉瘤、脂肪肉瘤、尤文氏肉瘤和腺泡状软组织肉瘤中未见免疫反应。小于15%的平滑肌、纤维或纤维组织细胞来源的肿瘤显示免疫反应性，通常是局灶性的。相反，在神经源性肿瘤中观察到高频率的免疫反应性（74%）。这包括颗粒细胞瘤（100%）、神经鞘瘤/神经纤维瘤（91%）、恶性神经鞘瘤（78%）、神经母细胞瘤/神经上皮瘤（60%）和副神经节瘤（57%）。在滑膜肉瘤（80%）、未分化肉瘤（60%）和血管外皮细胞瘤（43%）中也观察到高反应率，表明与神经表型的潜在关系。在神经肿瘤中，布因固定上级福尔马林，这表明NGF-R的免疫反应性受固定的影响。这种抗体可能是一个有用的辅助诊断标志物。
Identification of growth factors and receptors in mesenchymal tumors may be crucial to understanding of growth regulation in sarcomas. During an immunohistochemical study of the expression of growth factors and receptors in human soft tissue tumors (STT), only 1 antisera capable of working in paraffin-embedded tissue was noted. A detailed study of 141 STT was undertaken to determine the frequency of expression of nerve growth factor receptor (NGF-R), its specificity and sensitivity for neural tumors, and the effect of fixation on detection. In normal mesenchymal tissue, only nerve sheath and perivascular staining was seen. No immunoreactivity was seen in many tumors including rhabdomyosarcoma, angiosarcoma, liposarcoma, Ewing's sarcoma, and alveolar soft part sarcoma. Less than 15% of tumors of smooth muscle, fibrous, or fibrohistiocytic origin showed immunoreactivity, usually focal. In contrast, a high frequency of immunoreactivity was noted in tumors of neural origin (74%). This included granular cell tumors (100%), Schwannoma/neurofibroma (91%), malignant Schwannoma (78%), neuroblastoma/neuroepithelioma (60%), and paraganglioma (57%). A high rate of reactivity was also seen in synovial sarcomas (80%), undifferentiated sarcomas (60%), and hemangiopericytomas (43%), suggesting a potential relationship to the neural phenotype. Among the neural tumors, Bouin's fixation was superior to formalin, suggesting that immunoreactivity for NGF-R is affected by fixation. This antibody may be a useful adjunct marker diagnostically.
登录
查看更多内容
血小板衍生生长因子：正常细胞和转化细胞中的结构、功能和作用。
DOI：
10.1016/b978-0-12-152826-3.50012-7
发表时间：
1985
期刊：
Current topics in cellular regulation
影响因子：
--
作者：
Deuel,TF;Tong,BD;Huang,JS
通讯作者：
Huang,JS
神经胶质细胞上的 β 神经生长因子 (β NGF) 受体。
DOI：
10.1002/j.1460-2075.1983.tb01517.x
发表时间：
1983
期刊：
The EMBO journal
影响因子：
--
作者：
Zimmermann,A;Sutter,A
通讯作者：
Sutter,A
正常和神经纤维瘤雪旺细胞表达黑色素瘤相关抗原。
影响因子：
11.2
作者：
Ross,AH;Pleasure,D;Sonnenfeld,K;Atkinson,B;Kreider,B;Jackson,DM;Taff,I;Scarpini,E;Lisak,RP;Koprowski,H
通讯作者：
Koprowski,H
使用单克隆抗体表征神经嵴肿瘤中的神经生长因子受体。
DOI：
10.1073/pnas.81.21.6681
发表时间：
1984
影响因子：
11.1
作者：
Ross,AH;Grob,P;Bothwell,M;Elder,DE;Ernst,CS;Marano,N;Ghrist,BF;Slemp,CC;Herlyn,M;Atkinson,B
通讯作者：
Atkinson,B