Prognostic impact of CD168 expression in gastric cancer.
Prognostic impact of CD168 expression in gastric cancer.
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DOI：
10.1186/1471-2407-11-106
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发表时间：
2011-03-24
期刊：
影响因子：
3.8
通讯作者：
Natsugoe S
中科院分区：
文献类型：
--
作者：
Ishigami S;Ueno S;Nishizono Y;Matsumoto M;Kurahara H;Arigami T;Uchikado Y;Setoyama T;Arima H;Yoshiaki K;Kijima Y;Kitazono M;Natsugoe S
基质透明质酸(HA)与其结合蛋白RHAMM(HA介导的运动受体)(CD168)的相互作用可影响肿瘤的生长和关键分子的迁移，从而促进肿瘤的进展和转移。在几种癌症中，CD168的表达与侵袭性生物学特征相关。然而，CD168在胃癌中的临床意义仍不清楚。应用免疫组织化学方法检测196例胃癌组织中CD168的表达。根据CD168阳性将196例胃癌患者分为两组(57例CD168阳性和139例CD168阴性)。根据日本胃癌分类标准，评估CD168表达与临床病理因素(年龄、性别、组织学、肿瘤深度、淋巴结状况和血管侵犯)的相关性。196个肿瘤中有57个肿瘤表达癌CD168(29%)。CD168阳性表达与肿瘤侵犯深度、淋巴结转移和血管侵犯显著相关(p<；0.01)。对196例胃癌患者的生存分析显示，CD168阳性组的死亡率显著高于CD168阴性组(P<；0.01)。多因素分析显示，CD168表达是肿瘤侵袭深度(p<；0.013)和淋巴结转移(p<；0.005)的独立预后指标(p=0.005)。提示癌组织CD168阳性表达与胃癌的侵袭转移密切相关。提示CD168可通过与基质透明质酸的相互作用，作为判断胃癌预后的指标。
Interactions of stromal hyaluronic acid (HA) with its binding protein RHAMM (receptor for HA-mediated motility) (CD168) have been reported to affect tumor extension and the migration of crucial molecules to promote tumor progression and metastases. Cancerous CD168 expression is correlated with aggressive biological features in several cancers. However, the clinical implications of CD168 positivity in gastric cancer have remained unclear. We examined the CD168 expression of 196 consecutive gastric cancer patients by immunohistochemistry. According to CD168 positivity, the 196 gastric cancer patients were divided into two groups (57 CD168-positive and 139 CD168-negative patients). The correlation between CD168 expression and clinicopathological factors (age, sex, histology, tumor depth, lymph node status, and vessel invasion) was evaluated according to the Japanese Classification of Gastric Carcinoma. Cancerous CD168 expression was detectable in 57 of the 196 tumors (29%). CD168 positivity was significantly correlated with the depth of invasion, nodal involvement, and vessel invasion (p < 0.01). Survival analysis of the 196 gastric cancer patients showed that the CD168-positive group had a significantly higher mortality than the CD168-negative group (p < 0.01). In terms of a correlation with CD168 positivity at separate clinical stages, a significance difference was only found in stages II and III. Multivariate analysis revealed that CD168 expression was a significant independent prognostic marker (p = 0.013) after depth of invasion (p < 0.005) and nodal involvement (p < 0.01). Our results suggest that cancerous CD168 positivity is strongly related to the invasion and metastasis of gastric cancer tumors. These results suggest that cancerous CD168 expression can be used as a prognostic marker of gastric cancer owing to its interactions with stromal hyaluronic acid.
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影响因子：
11.5
作者：
Zlobec, Inti;Baker, Kristi;Lugli, Alessandro
通讯作者：
Lugli, Alessandro
影响因子：
8.8
作者：
Zlobec, I.;Baker, K.;Terracciano, L.;Peter, S.;Degen, L.;Beglinger, C.;Lugli, A.
通讯作者：
Lugli, A.
影响因子：
4.3
作者：
Sohr, Sindy;Engeland, Kurt
通讯作者：
Engeland, Kurt
DOI：
10.1007/s00432-003-0415-0
发表时间：
2003-03-01
影响因子：
3.6
作者：
Rein, DT;Roehrig, K;Dall, P
通讯作者：
Dall, P
DOI：
10.1111/j.1349-7006.1999.tb00846.x
发表时间：
1999-09
期刊：
Japanese journal of cancer research : Gann
影响因子：
--
作者：
Yamada Y;Itano N;Narimatsu H;Kudo T;Hirohashi S;Ochiai A;Niimi A;Ueda M;Kimata K
通讯作者：
Kimata K