Obesity alters the in vivo mechanical response and biochemical properties of cartilage as measured by MRI.
Obesity alters the in vivo mechanical response and biochemical properties of cartilage as measured by MRI.
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DOI：
10.1186/s13075-018-1727-4
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发表时间：
2018-10-17
影响因子：
4.9
通讯作者：
DeFrate LE
中科院分区：
文献类型：
--
作者：
Collins AT;Kulvaranon ML;Cutcliffe HC;Utturkar GM;Smith WAR;Spritzer CE;Guilak F;DeFrate LE
肥胖是膝骨关节炎（OA）发展的主要危险因素。然而，关于肥胖对膝关节软骨力学和组成影响的体内数据仍然缺乏。本研究的目的是确定肥胖和胫股软骨特性之间的关系。对体重指数（BMI）正常（n = 8）或高（n = 7）的健康受试者，在跑步机行走前后，分别获得了膝关节软骨几何形状（双回声稳态）和膝关节T1rho松弛的磁共振图像（3T）。受试者无下肢损伤史或手术史。对骨和软骨表面进行分割，并创建三维模型来测量软骨的厚度和应变。在运动前测量胫骨和股软骨的T1rho松弛时间，以表征生化成分。还测量了身体脂肪成分。BMI高的受试者胫股软骨劳损和T1rho松弛时间显著增加（P <0.05）。BMI对运动前胫骨软骨厚度也有影响（P <0.05）。相关分析显示，运动前胫骨软骨厚度随BMI （R2 = 0.43, P <0.01）和体脂率（R2 = 0.58, P <0.01）的增加而降低。胫骨和股骨软骨劳损随BMI （R2 = 0.45, P <0.01; R2 = 0.51, P <0.01）和体脂率（R2 = 0.40, P <0.05; R2 = 0.38, P <0.05）的增加而增加。胫骨T1rho与BMI （R2 = 0.39, P <0.05）、体脂率（R2 = 0.47, P <0.01）呈正相关。与BMI正常者相比，高BMI者胫股软骨的应变和T1rho松弛时间增加。此外，运动前胫骨软骨厚度随肥胖而减少。蛋白聚糖含量的减少可能是症状前骨关节炎退行性变的指示，导致软骨厚度减少，软骨变形增加，以响应载荷。
Obesity is a primary risk factor for the development of knee osteoarthritis (OA). However, there remains a lack of in vivo data on the influence of obesity on knee cartilage mechanics and composition. The purpose of this study was to determine the relationship between obesity and tibiofemoral cartilage properties. Magnetic resonance images (3T) of cartilage geometry (double-echo steady-state) and T1rho relaxation of the knee were obtained in healthy subjects with a normal (n = 8) or high (n = 7) body mass index (BMI) before and immediately after treadmill walking. Subjects had no history of lower limb injury or surgery. Bone and cartilage surfaces were segmented and three-dimensional models were created to measure cartilage thickness and strain. T1rho relaxation times were measured before exercise in both the tibial and femoral cartilage in order to characterize biochemical composition. Body fat composition was also measured. Subjects with a high BMI exhibited significantly increased tibiofemoral cartilage strain and T1rho relaxation times (P <0.05). Tibial pre-exercise cartilage thickness was also affected by BMI (P <0.05). Correlational analyses revealed that pre-exercise tibial cartilage thickness decreased with increasing BMI (R2 = 0.43, P <0.01) and body fat percentage (R2 = 0.58, P <0.01). Tibial and femoral cartilage strain increased with increasing BMI (R2 = 0.45, P <0.01; R2 = 0.51, P <0.01, respectively) and increasing body fat percentage (R2 = 0.40, P <0.05; R2 = 0.38, P <0.05, respectively). Additionally, tibial T1rho was positively correlated with BMI (R2 = 0.39, P <0.05) and body fat percentage (R2 = 0.47, P <0.01). Strains and T1rho relaxation times in the tibiofemoral cartilage were increased in high BMI subjects compared with normal BMI subjects. Additionally, pre-exercise tibial cartilage thickness decreased with obesity. Reduced proteoglycan content may be indicative of pre-symptomatic osteoarthritic degeneration, resulting in reduced cartilage thickness and increased deformation of cartilage in response to loading.
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影响因子：
2
作者：
ALEXANDER, RM;JAYES, AS
通讯作者：
JAYES, AS
影响因子：
4.6
作者：
Aygun AD;Gungor S;Ustundag B;Gurgoze MK;Sen Y
通讯作者：
Sen Y
DOI：
10.1002/art.39460
发表时间：
2016-03
期刊：
Arthritis & rheumatology (Hoboken, N.J.)
影响因子：
--
作者：
Coleman MC;Ramakrishnan PS;Brouillette MJ;Martin JA
通讯作者：
Martin JA
影响因子：
6.6
作者：
Honda, K;Ohno, S;Tanne, K
通讯作者：
Tanne, K
DOI：
10.1007/s004290050291
发表时间：
1999-10-01
期刊：
ANATOMY AND EMBRYOLOGY
影响因子：
--
作者：
Eckstein, F;Tieschky, M;Reiser, M
通讯作者：
Reiser, M