ApoE alleles, depression and positive affect in multiple sclerosis.
ApoE alleles, depression and positive affect in multiple sclerosis.
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DOI：
10.1177/1352458508099478
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发表时间：
2009-03
期刊：
影响因子：
--
通讯作者：
Mohr DC
中科院分区：
文献类型：
--
作者：
Julian LJ;Vella L;Frankel D;Minden SL;Oksenberg JR;Mohr DC
载脂蛋白E（ApoE）等位基因在抑郁症中的作用最近受到关注，ApoE ε4赋予更大的风险，导致更差的结局，ApoE ε2等位基因提供一些保护作用。抑郁症在多发性硬化症（MS）中很常见，ApoE等位基因的作用尚不清楚。评价参与Sonya Slifka纵向多发性硬化研究（Slifka研究）的MS患者队列中ApoE等位基因与抑郁症状的关系。为了检查风险和保护，分别对ApoE ε4和ApoE ε2等位基因的抑郁情绪和积极情感进行了研究。在101例受试者中，22.8%为ApoE ε2携带者，21.8%为ApoE ε4携带者。分层线性回归分析表明，在控制人口统计学、疾病持续时间和残疾后，ApoE ε2显著预测积极情感增加（R2Δ = 0.05，F（1，94）= 5.44，P = 0.02），并与抑郁症状严重程度的降低相关，但未达到统计学显著性（R2Δ = 0.03，F（1，94）= 3.44，P = 0.06）。ApoE ε4对抑郁状态无显著预测作用。在这项研究中，ApoE ε2等位基因的存在被认为是对我们从Slifka研究中招募的患者子样本中的抑郁症状的保护。这些发现与精神病人群中ApoE ε2与抑郁症发病率降低相关的报告一致。进一步的研究将是必要的，以了解载脂蛋白E基因型和抑郁症状的风险的作用。
The role of apolipoprotein E (ApoE) alleles has received recent attention in depressive disorders, the ApoE ε4 conferring greater risk for poorer outcomes, and the ApoE ε2 allele providing some protective effects. Depression is common in multiple sclerosis (MS) and the role of ApoE alleles is unknown. To evaluate ApoE alleles in relation to symptoms of depression in a cohort of patients with MS participating in the Sonya Slifka Longitudinal Multiple Sclerosis Study (Slifka Study). To examine risk and protection, depressed mood and positive affect were each investigated with respect to the ApoE ε4 and ApoE ε2 alleles, respectively. Of the total 101 participants, 22.8% were ApoE ε2 carriers and 21.8% were ApoE ε4 carriers. Hierarchical linear regression analyses suggested that after controlling for demographics, disease duration, and disability, ApoE ε2 significantly predicted increased positive affect (R2Δ = 0.05, F(1,94) = 5.44, P = 0.02) and was associated with decreased severity of depressive symptoms, although this did not reach statistical significance (R2Δ = 0.03, F(1,94) = 3.44, P = 0.06). ApoE ε4 did not significantly predict depression status. The presence of the ApoE ε2 allele in this study is suggested to be protective against depressive symptoms in our subsample of patients recruited from the Slifka Study. These findings are consistent with reports in psychiatric populations linking ApoE ε2 with decreased incidence of depressive disorders. Further investigation would be warranted to understand the role of ApoE genotypes and risk for depressive symptoms.
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