Spectrum of tau pathologies in Huntington's disease.

Spectrum of tau pathologies in Huntington's disease.
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DOI:
10.1038/s41374-018-0166-9
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发表时间:
2019-07
影响因子:
5
通讯作者:
Kofler, Julia
Kofler, Julia
中科院分区:
医学2区
文献类型:
--
作者:
Baskota, Swikrity Upadhyay;Lopez, Oscar L.;Greenamyre, J. Timothy;Kofler, Julia

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亨廷顿病(HD)是由亨廷顿基因中的三核苷酸扩增引起的常染色体显性遗传疾病。最近,一个新的作用,tau蛋白已被牵连在发病机制的HD,而其他人认为,死后tau蛋白的病理结果是由于并发阿尔茨海默病的病理。尚未详细检查HD中其他明确定义的常见年龄相关tau病理的频率。
Huntington’s disease (HD) is an autosomal dominant disorder caused by a trinucleotide expansion in the huntingtin gene. Recently, a new role for tau has been implicated in the pathogenesis of HD, while others have argued that postmortem tau pathology findings are attributable to concurrent Alzheimer’s disease pathology. The frequency of other well-defined common age-related tau pathologies in HD has not been examined in detail.
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