COVID-19 vaccination among young people who use drugs in Vancouver, Canada.
COVID-19 vaccination among young people who use drugs in Vancouver, Canada.
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加拿大温哥华吸毒年轻人接种了 COVID-19 疫苗。
DOI：
10.1016/j.vaccine.2024.01.003
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发表时间：
2024
期刊：
影响因子：
5.5
通讯作者：
DeBeck,Kora
中科院分区：
文献类型：
--
作者：
McAdam,Erica;Hayashi,Kanna;Barker,Brittany;Reddon,Hudson;Choi,JinCheol;Kerr,Thomas;DeBeck,Kora
目的SARS-CoV-2疫苗除了减少社区传播外，还能显著预防COVID-19导致的严重疾病和死亡。新兴的研究已经确定了与吸毒成年人接种疫苗相关的因素;然而，对吸毒青年和年轻人的了解较少。为了解决这一差距，我们试图描述与疫苗的吸收和探索疫苗犹豫YWUD.MethodsData之间的因素来自高危青年研究，一个前瞻性队列的街头参与YWUD在温哥华，加拿大。使用多变量logistic回归，我们描述了2021年6月至11月期间与SARS-CoV-2疫苗接种相关的因素。疫苗hesitancy的数据也covered.ResultsAmong 301名参与者参加了这项研究（中位年龄：29 [最小和最大：20-40]），151（50.2%）自我报告收到至少一个剂量的SARS-CoV-2疫苗。在多变量分析中，疫苗摄入与最近的成瘾治疗（调整后的比值比[AOR] = 2.46，95%置信区间[CI]：1.47-4.14）和接受规定的更安全的供应（例如，阿片类药物、兴奋剂）（AOR = 2.33，95% CI：1.03-5.62）。那些报告至少每周使用快克的人接种疫苗的可能性显著降低（AOR = 0.35，95% CI：0.12-0.92）。最报告的原因疫苗犹豫是安全问题，特别是关于长期的副作用（27.4%）。ConclusionVaccine uptake是显着低于YWUD比成人谁使用药物在温哥华和一般人口在不列颠哥伦比亚省，其中75%和93%，在同一时期收到至少一剂。研究结果表明，将YWUD与医疗保健和新的减少危害干预措施联系起来可能会增加疫苗的使用。对疫苗犹豫问题的回答揭示了疫苗的复杂观点，这些观点与普通人群中疫苗犹豫的来源一致。可以制定更广泛的战略，打击错误信息，促进基于证据的疫苗信息，以解决YWUD的独特需求和障碍。
ObjectivesSARS-CoV-2 vaccines provide significant protection against severe illness and death from COVID-19, in addition to reducing community transmission. Emerging research has identified factors associated with vaccine uptake among adults who use drugs; however, less is known about youth and young adults who use drugs (YWUD). To address this gap, we sought to characterize factors associated with vaccine uptake and explore vaccine hesitancy among YWUD.MethodsData were derived from the At-Risk Youth Study, a prospective cohort of street-involved YWUD in Vancouver, Canada. Using multivariable logistic regression, we characterized factors associated with SARS-CoV-2 vaccine uptake between June and November 2021. Data on vaccine hesitancy were also collected.ResultsAmong 301 participants enrolled in this study (median age: 29 [min and max: 20–40]), 151 (50.2%) self-reported receipt of at least one dose of a SARS-CoV-2 vaccine. In multivariable analysis, vaccine uptake was significantly associated with recent addiction treatment engagement (adjusted odds ratio [AOR] = 2.46, 95% confidence interval [CI]: 1.47–4.14) and receiving prescribed safer supply (e.g., opioids, stimulants) (AOR = 2.33, 95% CI: 1.03–5.62). Those who reported at least weekly crack use were significantly less likely to be vaccinated (AOR = 0.35, 95% CI: 0.12–0.92). The most reported reason for vaccine hesitancy was safety concerns, specifically regarding long-term side effects (27.4%).ConclusionVaccine uptake was significantly lower among YWUD than adults who use drugs in Vancouver and the general population in British Columbia, among whom 75% and 93% received at least one dose during the same period. Study findings suggest connecting YWUD to healthcare and novel harm reduction interventions may increase vaccine uptake. Responses to vaccine hesitancy questions revealed complex perspectives of vaccines that were aligned with sources of vaccine hesitancy among the general population. Broader strategies combatting misinformation and promoting evidence-based vaccine information could be tailored to address the unique needs and barriers experienced by YWUD.
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