Asthma symptoms in Hispanic children and daily ambient exposures to toxic and criteria air pollutants.

Asthma symptoms in Hispanic children and daily ambient exposures to toxic and criteria air pollutants.
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DOI:
10.1289/ehp.5992
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发表时间:
2003-04
影响因子:
10.4
通讯作者:
Hu Y
Hu Y
中科院分区:
环境科学与生态学1区
文献类型:
--
作者:
Delfino RJ;Gong H Jr;Linn WS;Pellizzari ED;Hu Y

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虽然美国环境保护署的主要标准空气污染物经常发现对哮喘的急性不良反应,但关于有毒排放源的特定碳氢化合物的流行病学信息很少。我们对22名10-16岁的西班牙裔哮喘儿童进行了一项小组研究,他们居住在交通密度高的洛杉矶社区。受试者每天填写症状日记长达3个月(1999年11月至2000年1月)。污染物包括臭氧、二氧化氮、二氧化硫和一氧化碳的每小时环境值以及挥发性有机化合物(VOCs)、空气动力学直径< 10微米的颗粒物(PM10)和元素碳(EC)和有机碳(OC)PM10分数的24小时值。使用广义估计方程回归哮喘症状严重程度与污染物的关系,使用混合模型回归呼气峰流速(PEF)与污染物的关系。我们发现症状与标准空气污染物(O3,NO2,SO2,PM10),EC-OC和VOC(苯,甲醛,乙醛,丙酮,1,3-丁二烯,四氯乙烯,甲苯,间,对二甲苯和邻二甲苯)呈正相关。污染物四分位数范围增加导致的恼人或更严重哮喘症状的选定校正比值比为:1.4 ppb 8小时NO2,1.27 [95%置信区间(CI),1.05-1.54]; 1.00 ppb苯,1.23(95% CI,1.02-1.48); 3.16 ppb甲醛,1.37(95% CI,1.04-1.80); 37微克/立方米PM10,1.45(95% CI,1.11-1.90); 2.91微克/立方米EC,1.85(95% CI,1.11-3.08);和4.64微克/立方米OC,1.88(95% CI,1.12-3.17)。EC或OC与PM10的双污染物模型显示EC(至1.83)或OC(至1.89)的比值比变化不大,但PM10从1.45降至1.0。与PEF无显著相关性。研究结果支持这样一种观点,即交通和工业来源的污染物混合物中的空气毒素可能对儿童哮喘产生不利影响。
Although acute adverse effects on asthma have been frequently found for the U.S. Environmental Protection Agency's principal criteria air pollutants, there is little epidemiologic information on specific hydrocarbons from toxic emission sources. We conducted a panel study of 22 Hispanic children with asthma who were 10-16 years old and living in a Los Angeles community with high traffic density. Subjects filled out symptom diaries daily for up to 3 months (November 1999 through January 2000). Pollutants included ambient hourly values of ozone, nitrogen dioxide, sulfur dioxide, and carbon monoxide and 24-hr values of volatile organic compounds (VOCs), particulate matter with aerodynamic diameter < 10 microm (PM10, and elemental carbon (EC) and organic carbon (OC) PM10 fractions. Asthma symptom severity was regressed on pollutants using generalized estimating equations, and peak expiratory flow (PEF) was regressed on pollutants using mixed models. We found positive associations of symptoms with criteria air pollutants (O3, NO2, SO2, PM10), EC-OC, and VOCs (benzene, ethylbenzene, formaldehyde, acetaldehyde, acetone, 1,3-butadiene, tetrachloroethylene, toluene, m,p-xylene, and o-xylene). Selected adjusted odds ratios for bothersome or more severe asthma symptoms from interquartile range increases in pollutants were, for 1.4 ppb 8-hr NO2, 1.27 [95% confidence interval (CI), 1.05-1.54]; 1.00 ppb benzene, 1.23 (95% CI, 1.02-1.48); 3.16 ppb formaldehyde, 1.37 (95% CI, 1.04-1.80); 37 microg/m3 PM10, 1.45 (95% CI, 1.11-1.90); 2.91 microg/m3 EC, 1.85 (95% CI, 1.11-3.08); and 4.64 microg/m3 OC, 1.88 (95% CI, 1.12-3.17). Two-pollutant models of EC or OC with PM10 showed little change in odds ratios for EC (to 1.83) or OC (to 1.89), but PM10 decreased from 1.45 to 1.0. There were no significant associations with PEF. Findings support the view that air toxins in the pollutant mix from traffic and industrial sources may have adverse effects on asthma in children.
DOI: 10.1289/ehp.02110s4505
发表时间: 2002-08
影响因子: 10.4
作者:
Leikauf GD
通讯作者: Leikauf GD
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影响因子: 10.4
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影响因子: 10.4
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发表时间: 2000-02-01
期刊: PEDIATRICS
影响因子: 8
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