Evolution of Darwin's Peloric Gloxinia (Sinningia speciosa) Is Caused by a Null Mutation in a Pleiotropic TCP Gene.
Evolution of Darwin's Peloric Gloxinia (Sinningia speciosa) Is Caused by a Null Mutation in a Pleiotropic TCP Gene.
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达尔文的腹膜大岩桐（Sinningia spiosa）的进化是由多效性 TCP 基因的无效突变引起的
DOI：
10.1093/molbev/msy090
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发表时间：
2018-08-01
影响因子：
10.7
通讯作者：
Wang YZ
中科院分区：
文献类型：
--
作者：
Dong Y;Liu J;Li PW;Li CQ;Lü TF;Yang X;Wang YZ
与大多数作物不同的是，大多数作物是通过古代人类长期的选择来驯化的，而园艺植物主要是通过短期的有意选择来驯化的。在园艺植物中，在驯化过程中潜在的新性状起源和传播的分子机制在很大程度上仍然没有被探索。Gloxinia(Sininegia Orosa)自19世纪初开始栽培，其诱人的盆花影响了达尔文的思想，但其起源和遗传基础目前尚不清楚。通过采用遗传分析、基因型-表型关联、基因表达分析和功能询问等多种实验方法，我们发现编码一个tcp蛋白的单基因SsCyC同时控制着Gloxinia的开花方向和合型。我们发现导致骨盆Gloxinia发生的一个原因突变存在于SsCyC编码序列的10个碱基缺失。通过遗传推断和文献检索相结合的方法，我们追踪到了可能的祖先，并重建了盆栽Gloxinia的驯化路径，其中SsCyC在选择下的10个碱基的缺失引发了它从野生祖先的进化。这些结果表明，在强烈的选择压力下，多效性基因的简单遗传变化可以促进花器官的发育。
Unlike most crops, which were domesticated through long periods of selection by ancient humans, horticultural plants were primarily domesticated through intentional selection over short time periods. The molecular mechanisms underlying the origin and spread of novel traits in the domestication process have remained largely unexplored in horticultural plants. Gloxinia (Sinningia speciosa), whose attractive peloric flowers influenced the thoughts of Darwin, have been cultivated since the early 19th century, but its origin and genetic basis are currently unknown. By employing multiple experimental approaches including genetic analysis, genotype–phenotype associations, gene expression analysis, and functional interrogations, we showed that a single gene encoding a TCP protein, SsCYC, controls both floral orientation and zygomorphy in gloxinia. We revealed that a causal mutation responsible for the development of peloric gloxinia lies in a 10-bp deletion in the coding sequence of SsCYC. By combining genetic inference and literature searches, we have traced the putative ancestor and reconstructed the domestication path of the peloric gloxinia, in which a 10-bp deletion in SsCYC under selection triggered its evolution from the wild progenitor. The results presented here suggest that a simple genetic change in a pleiotropic gene can promote the elaboration of floral organs under intensive selection pressure.
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