Vision and vision-related outcome measures in multiple sclerosis.
Vision and vision-related outcome measures in multiple sclerosis.
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DOI：
10.1093/brain/awu335
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发表时间：
2015-01
期刊：
影响因子：
--
通讯作者：
Cohen JA
中科院分区：
文献类型：
--
作者：
Balcer LJ;Miller DH;Reingold SC;Cohen JA
视力障碍是多发性硬化症的主要表现，与生活质量下降有关。Balcer等人回顾了目前关于多发性硬化症视力和视力结果的知识，并为视力损害的管理、临床试验的进行和未来研究的主题提供了建议。视觉障碍是多发性硬化症的重要表现。急性视神经炎是一种常见的、经常出现的表现，但即使没有视神经炎史，也可能发生视觉缺陷和视网膜轴突和神经元完整性的结构性丧失。对多发性硬化症视力的兴趣正在增长，部分原因是由于敏感视觉功能测试的发展，光学相干断层扫描和磁共振成像等结构标记，以及为传入视觉通路特有的结构-功能相关性提供临床意义的生活质量测量。眼动异常在多发性硬化症中也很常见，但可用于实践和临床试验的定量评估方法并不容易获得。我们在此总结了一项全面的文献检索和最近一次国际会议上的讨论，该会议涉及多发性硬化症视觉结果的发展和研究，其首要目标是回顾该领域的现状并确定未来研究的领域。我们回顾了数据和原理，以帮助我们理解视力作为多发性硬化症临床实践和治疗试验结果评估模型的重要性。
Visual impairment is a key manifestation of multiple sclerosis, and correlates with reduced quality of life. Balcer et al. review current knowledge of vision and visual outcomes in multiple sclerosis, and provide recommendations for the management of visual impairment, the conduct of clinical trials, and topics for future research. Visual impairment is a key manifestation of multiple sclerosis. Acute optic neuritis is a common, often presenting manifestation, but visual deficits and structural loss of retinal axonal and neuronal integrity can occur even without a history of optic neuritis. Interest in vision in multiple sclerosis is growing, partially in response to the development of sensitive visual function tests, structural markers such as optical coherence tomography and magnetic resonance imaging, and quality of life measures that give clinical meaning to the structure-function correlations that are unique to the afferent visual pathway. Abnormal eye movements also are common in multiple sclerosis, but quantitative assessment methods that can be applied in practice and clinical trials are not readily available. We summarize here a comprehensive literature search and the discussion at a recent international meeting of investigators involved in the development and study of visual outcomes in multiple sclerosis, which had, as its overriding goals, to review the state of the field and identify areas for future research. We review data and principles to help us understand the importance of vision as a model for outcomes assessment in clinical practice and therapeutic trials in multiple sclerosis.
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影响因子：
4.4
作者：
Cohen, Jeffrey A.
通讯作者：
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通讯作者：
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