Macrophage migration inhibitory factor (MIF): a promising biomarker.
Macrophage migration inhibitory factor (MIF): a promising biomarker.
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DOI：
10.1358/dnp.2010.23.4.1453629
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发表时间：
2010-05
影响因子：
--
通讯作者：
Bucala R
中科院分区：
文献类型：
--
作者：
Grieb G;Merk M;Bernhagen J;Bucala R
巨噬细胞移动抑制因子（MIF）是一种免疫调节细胞因子，几十年前就认识到其抑制免疫细胞随机运动的作用。尽管其历史名称，MIF也有直接的趋化因子样功能，并促进细胞募集。多项临床研究已经指出MIF作为具有炎症组分的不同疾病的生物标志物的效用;这些疾病包括全身性感染和败血症、自身免疫性疾病、癌症和代谢紊乱如2型糖尿病和肥胖症。MIF基因（MIF）功能启动子多态性的鉴定及其与不同疾病的易感性或严重程度的相关性不仅证实了MIF在疾病发展中的作用，而且开辟了利用MIF基因型信息更好地预测风险和结果的可能性。在这篇文章中，我们回顾了MIF的临床数据，并讨论了其作为不同疾病应用的生物标志物的潜力。
Macrophage migration inhibitory (MIF) factor is an immunoregulatory cytokine whose effect on arresting random immune cell movement was recognized several decades ago. Despite its historic name, MIF also has a direct chemokine-like function and promotes cell recruitment. Multiple clinical studies have pointed to the utility of MIF as a biomarker for different diseases that have an inflammatory component; these include systemic infections and sepsis, autoimmune diseases, cancer, and metabolic disorders such as type 2 diabetes and obesity. The identification of functional promoter polymorphisms in the MIF gene (MIF) and their association with the susceptibility or severity of different diseases has served not only to validate MIF’s role in disease development but opened the possibility of using MIF genotype information to better predict risk and outcome. In this article, we review the clinical data of MIF and discuss its potential as a biomarker for different disease applications.
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