The phage-host arms race: shaping the evolution of microbes.

The phage-host arms race: shaping the evolution of microbes.
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DOI:
10.1002/bies.201000071
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发表时间:
2011-01
期刊:
影响因子:
4
通讯作者:
Sorek, Rotem
Sorek, Rotem
中科院分区:
生物学3区
文献类型:
--
作者:
Stern, Adi;Sorek, Rotem

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细菌是地球上最丰富的生物体,但感染细菌的噬菌体数量比细菌多 10 比 1。面对噬菌体颗粒的快速进化和周转,细菌进化出各种机制来逃避噬菌体的感染和杀伤,从而引发进化军备竞赛。噬菌体和宿主的广泛共同进化导致细菌和噬菌体的防御和进攻策略具有相当大的多样性。在这里,我们讨论噬菌体抗性机制的独特和共同特征及其在全球生物多样性中的作用。防御机制之间的共性为根据其进化特征发现新型此类机制提供了途径。
Bacteria, the most abundant organisms on the planet, are outnumbered by a factor of 10 to 1 by phages that infect them. Faced with the rapid evolution and turnover of phage particles, bacteria have evolved various mechanisms to evade phage infection and killing, leading to an evolutionary arms-race. The extensive co-evolution of both phage and host has resulted in considerable diversity on the part of both bacterial and phage defensive and offensive strategies. Here, we discuss the unique and common features of phage resistance mechanisms and their role in global biodiversity. The commonalities between defense mechanisms suggest avenues for the discovery of novel such mechanisms based on their evolutionary traits.
细菌程序性细胞死亡和细菌多细胞行为。
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