Elevated risk of colorectal, liver, and pancreatic cancers among HCV, HBV and/or HIV (co)infected individuals in a population based cohort in Canada.
Elevated risk of colorectal, liver, and pancreatic cancers among HCV, HBV and/or HIV (co)infected individuals in a population based cohort in Canada.
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DOI：
10.1177/1758835921992987
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发表时间：
2021
影响因子：
4.9
通讯作者：
Janjua NZ
中科院分区：
文献类型：
--
作者：
Darvishian M;Butt ZA;Wong S;Yoshida EM;Khinda J;Otterstatter M;Yu A;Binka M;Rossi C;McKee G;Pearce M;Alvarez M;Wong J;Cook D;Grennan T;Buxton J;Tyndall M;Woods R;Krajden M;Bhatti P;Janjua NZ
关于丙型肝炎病毒（HCV）、乙型肝炎病毒（HBV）和单一艾滋病毒（HIV）以及合并感染对癌症（特别是肝癌）风险影响的研究有限，研究结果也不一致。在不列颠哥伦比亚省肝炎测试队列中，我们评估了与HCV、HBV和HIV感染状态相关的结直肠癌、肝癌和胰腺癌的风险。使用Fine和Gray调整比例亚分布风险模型，我们评估了感染状态对每种癌症的影响，并考虑了相互竞争的死亡风险。从BC省癌症登记处确定癌症发生情况。在对658,697人进行了三种感染的检测中，发现了1407例结直肠癌，1294例肝癌和489例胰腺癌。与未感染的个体相比，HCV（危险度[HR] 2.99； 95%可信区间[CI] 2.55-3.51）、HBV（危险度[HR] 2.47； 95%可信区间[CI] 1.85-3.28）、HIV单感染（危险度[HR] 2.30； 95%可信区间[CI] 1.47-3.59）和HCV/HIV合并感染的人群发生结直肠癌的风险显著升高。在HCV和HBV单一感染者和所有合并感染者中，肝癌的风险显著升高。HCV（风险比2.79,95% CI 2.01-3.70）、HIV单感染（风险比2.82,95% CI 1.39-5.71）和HCV/HBV合并感染的患者患胰腺癌的风险显著升高。与未感染者相比，HCV、HBV和/或HIV感染者患结直肠癌、胰腺癌和肝癌的风险升高。这些发现强调了在感染人群中进行有针对性的癌症预防和勤奋的肝癌和肝外癌临床监测的必要性。
Studies of the impact of hepatitis C virus (HCV), hepatitis B virus (HBV) and HIV mono and co-infections on the risk of cancer, particularly extra-hepatic cancer, have been limited and inconsistent in their findings. In the British Columbia Hepatitis Testers Cohort, we assessed the risk of colorectal, liver, and pancreatic cancers in association with HCV, HBV and HIV infection status. Using Fine and Gray adjusted proportional subdistribution hazards models, we assessed the impact of infection status on each cancer, accounting for competing mortality risk. Cancer occurrence was ascertained from the BC Cancer Registry. Among 658,697 individuals tested for the occurrence of all three infections, 1407 colorectal, 1294 liver, and 489 pancreatic cancers were identified. Compared to uninfected individuals, the risk of colorectal cancer was significantly elevated among those with HCV (Hazard ration [HR] 2.99; 95% confidence interval [CI] 2.55–3.51), HBV (HR 2.47; 95% CI 1.85–3.28), and HIV mono-infection (HR 2.30; 95% CI 1.47–3.59), and HCV/HIV co-infection. The risk of liver cancer was significantly elevated among HCV and HBV mono-infected and all co-infected individuals. The risk of pancreatic cancer was significantly elevated among individuals with HCV (HR 2.79; 95% CI 2.01–3.70) and HIV mono-infection (HR 2.82; 95% CI 1.39–5.71), and HCV/HBV co-infection. Compared to uninfected individuals, the risk of colorectal, pancreatic and liver cancers was elevated among those with HCV, HBV and/or HIV infection. These findings highlight the need for targeted cancer prevention and diligent clinical monitoring for hepatic and extrahepatic cancers in infected populations.
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影响因子：
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作者：
Allaire, Manon;Nahon, Pierre;Roudot-Thoraval, Francoise
通讯作者：
Roudot-Thoraval, Francoise
影响因子：
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作者：
Gjaerde, Lars I.;Shepherd, Leah;Peters, Lars
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Allison RD;Tong X;Moorman AC;Ly KN;Rupp L;Xu F;Gordon SC;Holmberg SD;Chronic Hepatitis Cohort Study (CHeCS) Investigators
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Chronic Hepatitis Cohort Study (CHeCS) Investigators
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作者：
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通讯作者：
Dobs, AS
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通讯作者：
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