Increased incidence of cancer and cancer-related mortality among persons with chronic hepatitis C infection, 2006-2010.
Increased incidence of cancer and cancer-related mortality among persons with chronic hepatitis C infection, 2006-2010.
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DOI：
10.1016/j.jhep.2015.04.021
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发表时间：
2015-10
影响因子：
25.7
通讯作者：
Chronic Hepatitis Cohort Study (CHeCS) Investigators
中科院分区：
文献类型：
--
作者：
Allison RD;Tong X;Moorman AC;Ly KN;Rupp L;Xu F;Gordon SC;Holmberg SD;Chronic Hepatitis Cohort Study (CHeCS) Investigators
慢性丙型肝炎（HCV）感染者可能比普通人群更容易患非肝癌和肝癌。因此，我们评估了美国四个大型卫生系统中HCV感染患者的癌症发病率和死亡率，为160多万成年人提供服务，并与2006年至2010年五年期间的普通人群进行了比较。慢性肝炎队列研究（CHeCS）中的12，126名慢性HCV感染者从2006年至2010年进行了39，984人年的随访，并与来自13个监测，流行病学和最终结果计划（SEER）癌症登记处的133，795，010份记录进行了比较，以及大约1200万份来自多原因死亡（MCOD）数据的美国死亡证明。分别计算发病率和死亡率的标准化率比（SRR）和相对危险度（RR）。以下癌症的发病率在慢性HCV感染患者中显著较高：肝（SRR，48.6 [95% CI，44.4-52.7]），胰腺（2.5 [1.7-3.2]）、直肠（2.1 [1.3-2.8]）、肾（1.7 [1.1-2.2]）、非霍奇金淋巴瘤（1.6 [1.2-2.1]）和肺（1.6 [1.3-1.9]）。以下癌症患者的经风险调整的死亡率显著较高：肝癌（RR，29.6 [95%CI，29.1-30.1]）、口腔癌（5.2 [5.1-5.4]）、直肠癌（2.6 [2.5-2.7]）、非霍奇金淋巴瘤（2.3 [2.2-2.31]）和胰腺癌（1.63 [1.6-1.7]）。与许多癌症的一般人群相比，CHeCS HCV队列患者的癌症诊断和癌症相关死亡的平均年龄显着年轻。与一般人群相比，慢性HCV感染患者中许多类型的非肝癌的发病率和死亡率更高，诊断和死亡年龄更年轻。
Persons chronically infected with hepatitis C (HCV) may be at higher risk for developing and dying from non-liver as well as liver cancers than the general population. We therefore assessed cancer incidence and mortality among HCV-infected patients in four large health systems in the United States serving over 1.6 million adults, and compared with rates for the general population during the five-year period from 2006 to 2010. 12,126 chronic HCV-infected persons in the Chronic Hepatitis Cohort Study (CHeCS) contributed 39,984 person-years of follow-up from 2006 to 2010, and were compared to 133,795,010 records from 13 Surveillance, Epidemiology and End Results Program (SEER) cancer registries, and approximately 12 million US death certificates from Multiple Cause of Death (MCOD) data. Standardized rate ratios (SRR) and relative risk (RR) were calculated for incidence and mortality, respectively. The incidence of the following cancers was significantly higher among patients with chronic HCV infection: liver (SRR, 48.6 [95% CI, 44.4–52.7]), pancreas (2.5 [1.7–3.2]), rectum (2.1 [1.3–2.8]), kidney (1.7 [1.1–2.2]), non-Hodgkin lymphoma (1.6 [1.2–2.1]), and lung (1.6 [1.3–1.9]). Age-adjusted mortality was significantly higher among patients with: liver (RR, 29.6 [95% CI, 29.1–30.1]), oral (5.2 [5.1–5.4]), rectum (2.6 [2.5–2.7]), non-Hodgkin lymphoma (2.3 [2.2–2.31]), and pancreatic (1.63 [1.6–1.7]) cancers. The mean age of cancer diagnosis and cancer-related death was significantly younger in CHeCS HCV cohort patients compared to the general population for many cancers. Incidence and mortality of many types of non-liver cancers were higher, and age at diagnosis and death younger, in patients with chronic HCV infection compared to the general population.
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DOI：
10.1002/hep.27422
发表时间：
2015-03
期刊：
Hepatology (Baltimore, Md.)
影响因子：
--
作者：
Boscarino JA;Lu M;Moorman AC;Gordon SC;Rupp LB;Spradling PR;Teshale EH;Schmidt MA;Vijayadeva V;Holmberg SD;Chronic Hepatitis Cohort Study (CHeCS) Investigators
通讯作者：
Chronic Hepatitis Cohort Study (CHeCS) Investigators
影响因子：
39.2
作者：
Denniston MM;Jiles RB;Drobeniuc J;Klevens RM;Ward JW;McQuillan GM;Holmberg SD
通讯作者：
Holmberg SD
影响因子：
11.8
作者：
Moorman, Anne C.;Gordon, Stuart C.;Holmberg, Scott D.
通讯作者：
Holmberg, Scott D.
影响因子：
6.4
作者：
De Sanjose, S;Nieters, A;Kallinowski, B
通讯作者：
Kallinowski, B
影响因子：
13.5
作者：
El-Serag, HB;Hampel, H;Rabeneck, L
通讯作者：
Rabeneck, L