Neuroimmune contributions to Alzheimer's disease: a focus on human data.
Neuroimmune contributions to Alzheimer's disease: a focus on human data.
复制标题
DOI：
10.1038/s41380-022-01637-0
复制
发表时间：
2022-08
影响因子：
11
通讯作者：
De Jager, Philip L.
中科院分区：
文献类型：
--
作者：
Haage, Verena;De Jager, Philip L.
在过去的十年中，出现了一系列新的见解，从遗传和系统分析阿尔茨海默病（AD）与丰富的流行病学数据从各个领域的融合;这导致了新的兴趣免疫反应作为重要的，潜在的因果组成部分的AD。在这里，我们主要关注对人类数据的回顾，这些数据最近产生了一组强大的，可重复的结果，这些结果存在于一个更大的冲突报告的范围内，这些报告来自小型研究，其研究设计存在重要限制。因此，我们正处于一个重要的十字路口，首先要了解在AD的长期，多相过程中的哪一步，给定的免疫反应可能发挥因果作用，然后调节这种反应，以减缓或阻断AD的病理生理。我们有丰富的新的实验工具，分析方法和能力，在大规模的纵向采样人类参与者;这些资源，当再加上可重复的结果和新的研究设计的基础，将使我们能够监测人类免疫功能的中枢神经系统的复杂性水平，同时捕获外周免疫系统的状态。外周和中枢扰动在免疫应答中的这种整合导致中枢神经系统实质中的病理应答，其中由多种细胞亚型组成的特化细胞微环境对这些免疫扰动以及环境暴露、合并症和生命进程的影响作出应答。在这里，我们提供了一个概述，试图说明大量的相互关联的因素，最终产生的AD的神经免疫成分。
The past decade has seen the convergence of a series of new insights that arose from genetic and systems analyses of Alzheimer’s disease (AD) with a wealth of epidemiological data from a variety of fields; this resulted in renewed interest in immune responses as important, potentially causal components of AD. Here, we focus primarily on a review of human data which has recently yielded a set of robust, reproducible results that exist in a much larger universe of conflicting reports stemming from small studies with important limitations in their study design. Thus, we are at an important crossroads in efforts to first understand at which step of the long, multiphasic course of AD a given immune response may play a causal role and then modulate this response to slow or block the pathophysiology of AD. We have a wealth of new experimental tools, analysis methods, and capacity to sample human participants at large scale longitudinally; these resources, when coupled to a foundation of reproducible results and novel study designs, will enable us to monitor human immune function in the CNS at the level of complexity that is required while simultaneously capturing the state of the peripheral immune system. This integration of peripheral and central perturbations in immune responses results in pathologic responses in the central nervous system parenchyma where specialized cellular microenvironments composed of multiple cell subtypes respond to these immune perturbations as well as to environmental exposures, comorbidities and the impact of the advancing life course. Here, we offer an overview that seeks to illustrate the large number of interconnecting factors that ultimately yield the neuroimmune component of AD.
登录
查看更多内容
影响因子：
16.2
作者：
Allnutt, Mary Alice;Johnson, Kory;Jacobson, Steven
通讯作者：
Jacobson, Steven
影响因子：
3.5
作者：
BAUER, J;STRAUSS, S;BERGER, M
通讯作者：
BERGER, M
影响因子：
4
作者：
Barrett, E.;Ross, R. P.;Stanton, C.
通讯作者：
Stanton, C.
影响因子：
16.2
作者：
Abud EM;Ramirez RN;Martinez ES;Healy LM;Nguyen CHH;Newman SA;Yeromin AV;Scarfone VM;Marsh SE;Fimbres C;Caraway CA;Fote GM;Madany AM;Agrawal A;Kayed R;Gylys KH;Cahalan MD;Cummings BJ;Antel JP;Mortazavi A;Carson MJ;Poon WW;Blurton-Jones M
通讯作者：
Blurton-Jones M
影响因子：
4.2
作者：
Cattaneo, Annamaria;Cattane, Nadia;Frisoni, Giovanni B.
通讯作者：
Frisoni, Giovanni B.