Atypical squamous cells of undetermined significance, human papillomavirus, and cervical intraepithelial neoplasia 2 or 3 in adolescents: ASC-US, age, and high-grade cervical neoplasia.

Atypical squamous cells of undetermined significance, human papillomavirus, and cervical intraepithelial neoplasia 2 or 3 in adolescents: ASC-US, age, and high-grade cervical neoplasia.
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意义未明的非典型鳞状细胞、人乳头瘤病毒和青少年宫颈上皮内瘤变 2 或 3:ASC-US、年龄和高级别宫颈瘤变。

DOI:
10.1097/00128360-200607000-00004
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发表时间:
2006
影响因子:
3.7
通讯作者:
Stanko,Cara
Stanko,Cara
中科院分区:
医学4区
文献类型:
--
作者:
Boardman,LoriA;Weitzen,Sherry;Stanko,Cara

文献摘要

参考文献

相似文献

目的:确定患有意义未明的非典型鳞状细胞 (ASC-US) 和致癌人乳头瘤病毒 (HPV) 感染的女性中宫颈上皮内瘤变 (CIN) 2 或 3 的发生率和相关因素。材料和方法。这是对 357 名患有 ASC-US 和已知高危 HPV 感染的女性的回顾性评价。为了符合纳入资格,患者必须随后接受阴道镜引导的宫颈活检和/或宫颈内取样。使用单变量和多变量回归分析来估计与 HPV 和 CIN 相关的危险因素的 CIN 2 或 3 的粗略和调整后的比值比。结果。215 名患有 ASC-US 和致癌 HPV 且接受组织学取样的女性中,有 33 名 (15%) 表现出 CIN 2 或 3。在调整后的模型中,仅未生育(调整后的比值比 = 2.2,95% CI= 1.0-4.8)与结果保持边际关联。重度疾病的患病率没有出现与年龄相关的显着差异。青少年中看到的高级别病变由单个小病变组成。结论。根据这些发现,并结合 ASC-US 青少年中致癌性 HPV 感染率较高,反射 HPV 检测和立即阴道镜检查似乎对具有这种细胞学诊断的青少年的初步治疗没有益处。
Objective.To determine rates of and factors associated with cervical intraepithelial neoplasia (CIN) 2 or 3 among women with atypical squamous cells of undetermined significance (ASC-US) and oncogenic human papillomavirus (HPV) infection.Materials and Methods.This is a retrospective review of 357 women with ASC-US and known high-risk HPV infection. To be eligible for inclusion, patients had to have subsequently undergone colposcopic-directed cervical biopsy and/or endocervical sampling. Univariate and multivariable regression analyses were used to estimate crude and adjusted odds ratios of CIN 2 or 3 by risk factors associated with HPV and CIN.Results.Thirty-three of 215 (15%) women with ASC-US and oncogenic HPV who underwent histological sampling demonstrated CIN 2 or 3. In the adjusted model, only nulliparity (adjusted odds ratio= 2.2, 95% CI= 1.0-4.8) retained a marginal association with the outcome. No significant age-related differences in the prevalence of high-grade disease emerged. The high-grade lesions seen in adolescents consisted of single, small lesions.Conclusions.In the light of these findings, and in conjunction with the high rate of oncogenic HPV infection among adolescents with ASC-US, both reflex HPV testing and immediate colposcopy do not appear to be of benefit in the initial management of teenagers with this cytological diagnosis.
性乱和吸毒成瘾的母亲所生婴儿患有 T4/T8 比例逆转的获得性免疫缺陷。
DOI: --
发表时间: 1983
期刊: JAMA : the journal of the American Medical Association
影响因子: --
作者:
Rubinstein,A;Sicklick,M;Gupta,A;Bernstein,L;Klein,N;Rubinstein,E;Spigland,I;Fruchter,L;Litman,N;Lee,H;Hollander,M
通讯作者: Hollander,M
新生儿艾滋病毒感染的早期检测。
DOI: 10.1056/nejm198701293160510
发表时间: 1987
期刊: The New England journal of medicine
影响因子: --
作者:
D. Harnish;O. Hammerberg;I. Walker;K. Rosenthal
通讯作者: K. Rosenthal
新生儿艾滋病毒感染的早期诊断。
DOI: --
发表时间: 1987
影响因子: 158.5
作者:
J. P. Johnson;P. Nair;S. Alexander
通讯作者: S. Alexander
儿童艾滋病:临床、流行病学和公共卫生方面的回顾
DOI: --
发表时间: 1985
期刊: Pediatric Infectious Disease
影响因子: --
作者:
M. Rogers
通讯作者: M. Rogers
DOI: 10.1001/jama.1986.03370170063036
发表时间: 1986
期刊: JAMA
影响因子: --
作者:
Savita Pahwa;Mark H. Kaplan;Senih Fikrig;R. Pahwa;M. Sarngadharan;Mikuláš Popovič;Robert C. Gallo
通讯作者: Robert C. Gallo