Atypical squamous cells of undetermined significance, human papillomavirus, and cervical intraepithelial neoplasia 2 or 3 in adolescents: ASC-US, age, and high-grade cervical neoplasia.
Atypical squamous cells of undetermined significance, human papillomavirus, and cervical intraepithelial neoplasia 2 or 3 in adolescents: ASC-US, age, and high-grade cervical neoplasia.
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意义未明的非典型鳞状细胞、人乳头瘤病毒和青少年宫颈上皮内瘤变 2 或 3:ASC-US、年龄和高级别宫颈瘤变。
DOI:
10.1097/00128360-200607000-00004
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发表时间:
2006
影响因子:
3.7
通讯作者:
Stanko,Cara
中科院分区:
文献类型:
--
作者:
Boardman,LoriA;Weitzen,Sherry;Stanko,Cara
Objective.To determine rates of and factors associated with cervical intraepithelial neoplasia (CIN) 2 or 3 among women with atypical squamous cells of undetermined significance (ASC-US) and oncogenic human papillomavirus (HPV) infection.Materials and Methods.This is a retrospective review of 357 women with ASC-US and known high-risk HPV infection. To be eligible for inclusion, patients had to have subsequently undergone colposcopic-directed cervical biopsy and/or endocervical sampling. Univariate and multivariable regression analyses were used to estimate crude and adjusted odds ratios of CIN 2 or 3 by risk factors associated with HPV and CIN.Results.Thirty-three of 215 (15%) women with ASC-US and oncogenic HPV who underwent histological sampling demonstrated CIN 2 or 3. In the adjusted model, only nulliparity (adjusted odds ratio= 2.2, 95% CI= 1.0-4.8) retained a marginal association with the outcome. No significant age-related differences in the prevalence of high-grade disease emerged. The high-grade lesions seen in adolescents consisted of single, small lesions.Conclusions.In the light of these findings, and in conjunction with the high rate of oncogenic HPV infection among adolescents with ASC-US, both reflex HPV testing and immediate colposcopy do not appear to be of benefit in the initial management of teenagers with this cytological diagnosis.
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DOI:
--
发表时间:
1983
期刊:
JAMA : the journal of the American Medical Association
影响因子:
--
作者:
Rubinstein,A;Sicklick,M;Gupta,A;Bernstein,L;Klein,N;Rubinstein,E;Spigland,I;Fruchter,L;Litman,N;Lee,H;Hollander,M
通讯作者:
Hollander,M
DOI:
10.1056/nejm198701293160510
发表时间:
1987
期刊:
The New England journal of medicine
影响因子:
--
作者:
D. Harnish;O. Hammerberg;I. Walker;K. Rosenthal
通讯作者:
K. Rosenthal
影响因子:
158.5
作者:
J. P. Johnson;P. Nair;S. Alexander
通讯作者:
S. Alexander
DOI:
--
发表时间:
1985
期刊:
Pediatric Infectious Disease
影响因子:
--
作者:
M. Rogers
通讯作者:
M. Rogers
DOI:
10.1001/jama.1986.03370170063036
发表时间:
1986
期刊:
JAMA
影响因子:
--
作者:
Savita Pahwa;Mark H. Kaplan;Senih Fikrig;R. Pahwa;M. Sarngadharan;Mikuláš Popovič;Robert C. Gallo
通讯作者:
Robert C. Gallo