Evaluation of current rapid HIV test algorithms in Rakai, Uganda.
Evaluation of current rapid HIV test algorithms in Rakai, Uganda.
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DOI：
10.1016/j.jviromet.2013.04.003
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发表时间：
2013-09
影响因子：
3.1
通讯作者：
Kigozi G
中科院分区：
文献类型：
--
作者：
Galiwango RM;Musoke R;Lubyayi L;Ssekubugu R;Kalibbala S;Ssekweyama V;Mirembe V;Nakigozi G;Reynolds SJ;Serwadda D;Gray RH;Kigozi G
快速艾滋病毒检测是资源有限环境中艾滋病毒诊断的重要组成部分。在乌干达，卫生部允许使用Determine、Stat-Pak和Uni-Gold进行连续和平行的艾滋病毒快速检测。在串行测试中，Determine上的非反应性结果结束测试。使用Determine和Stat-Pak检测试剂盒评估了串行和并行算法的性能。根据推荐的平行测试算法，使用三种快速HIV检测试剂盒进行横断面诊断测试准确性评估，然后进行EIA-WB测试，并估计系列测试算法的性能。在2520名被试中，0.6%的被试有弱反应。平行试验的敏感性为99.7%，特异性为99.8%。如果使用Stat-Pak作为系列算法的第一筛选试验，则灵敏度为99.6%，特异性为99.7%。然而，如果使用Determine作为筛选试验，则灵敏度为97.3%，特异性为99.9%。使用Stat-Pak作为初始筛选试验进行的系列试验以及平行试验，但Determine是一种不太敏感的筛选。系列测试可以节省成本。
Rapid HIV tests are a crucial component of HIV diagnosis in resource limited settings. In Uganda, the Ministry of Health allows for both serial and parallel HIV rapid testing using Determine, Stat-Pak and Uni-Gold. In serial testing, a non-reactive result on Determine ends testing. The performance of serial and parallel algorithms with Determine and Stat-Pak test kits was assessed. A cross-sectional diagnostic test accuracy evaluation using three rapid HIV test kits as per the recommended parallel test algorithm was followed by EIA-WB testing with estimates of the performance of serial testing algorithm. In 2520 participants tested by parallel rapid algorithms, 0.6% had weakly reactive result. Parallel testing had 99.7% sensitivity and 99.8% specificity. If Stat-Pak was used as the first screening test for a serial algorithm, the sensitivity was 99.6% and specificity 99.7%. However, if Determine was used as the screening test, sensitivity was 97.3% and specificity 99.9%. Serial testing with Stat-Pak as the initial screening test performed as well as parallel testing, but Determine was a less sensitive screen. Serial testing could be cost saving.
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影响因子：
3.8
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通讯作者：
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