Iron Metabolism in African American Women in the Second and Third Trimesters of High-Risk Pregnancies.
Iron Metabolism in African American Women in the Second and Third Trimesters of High-Risk Pregnancies.
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DOI：
10.1016/j.jogn.2016.06.013
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发表时间：
2017-01
期刊：
影响因子：
--
通讯作者：
Tussing-Humphreys L
中科院分区：
文献类型：
--
作者：
Welke L;Koenig MD;Thomson JL;Nemeth E;White-Traut R;McFarlin BL;Giurgescu C;Engeland CG;Kominiarek MA;Tussing-Humphreys L
研究高危妊娠的非裔美国妇女在第二和第三孕期的铁代谢。纵向试点研究。大型的，以大学为基础的，城市中西部医疗中心。32名非洲裔美国妇女的方便样本与高风险怀孕寻求照顾的城市，母胎医学诊所。在妊娠中期和妊娠晚期采集非空腹静脉血，以评估铁状态、铁调素和全身炎症。通过自我报告获得人体测量和调查数据。根据这些数据计算描述性统计量，并通过配对t检验评价妊娠中期和妊娠晚期之间临床参数的变化。在每三个月的人口统计学，生殖，人体测量，炎症和铁相关参数之间的关联也进行了评估。参与者的平均年龄为28.3（± 6.8）岁，孕前体重指数为31.9（± 10.7）kg/m2。在纵向分析中，观察到孕中期和孕晚期之间血清铁、铁蛋白、转铁蛋白饱和度和C反应蛋白的显著（p < 0.05）下降。在妊娠期之间，铁调素没有统计学显著变化。当使用< 15 ng/ml的铁蛋白临界点和> 28.1 nmol/l的可溶性转铁蛋白受体时，48%的参与者（29人中的14人）在孕晚期被归类为缺铁。在这项试点研究中，铁缺乏症在一小群高危妊娠的非洲裔美国妇女中普遍存在。铁调素浓度高于以前报告的健康，怀孕，主要是白色妇女，这表明降低铁的生物利用度在这个高风险的群体。在这个样本中，结果表明具有高风险妊娠的非裔美国妇女的铁生物利用度较低。
To examine iron metabolism during the second and third trimesters in African American women with high-risk pregnancies. Longitudinal pilot study. Large, university-based, urban Midwestern medical center. Convenience sample of 32 African American women with high-risk pregnancies seeking care at an urban, maternal-fetal medicine clinic. Non-fasting venous blood was collected in the second and third trimesters to assess iron status, hepcidin, and systemic inflammation. Anthropometric and survey data were obtained via self-report. Descriptive statistics were calculated from these data, and changes in the clinical parameters between the second and third trimester were evaluated via paired t-tests. Associations among demographic, reproductive, anthropometric, inflammatory and iron-related parameters were also assessed in each trimester. The mean age of participants was 28.3 (± 6.8) years, and pre-pregnancy body mass index was 31.9 (± 10.7) kg/m2. In the longitudinal analysis, significant (p < 0.05) declines in serum iron, ferritin, transferrin saturation, and C-reactive protein were observed between the second and third trimester. There was no statistically significant change in hepcidin between trimesters. When using a ferritin cut-point of < 15 ng/ml and soluble transferrin receptor > 28.1 nmol/l, 48% of the participants (14 of 29) were classified with iron deficiency in the third trimester. In this pilot study, iron deficiency was prevalent among a small cohort of African American women with high-risk pregnancies. Hepcidin concentrations were higher than previously reported in healthy, pregnant, primarily White women, which suggests decreased iron bioavailability in this high-risk group. In this sample, results indicated lower iron bioavailability in African American women with high-risk pregnancies.
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作者：
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