No time to lose--high throughput screening to assess nanomaterial safety.
No time to lose--high throughput screening to assess nanomaterial safety.
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没有时间丢失 - 高吞吐量筛查以评估纳米材料安全性。
作者：
Damoiseaux R;George S;Li M;Pokhrel S;Ji Z;France B;Xia T;Suarez E;Rallo R;Mädler L;Cohen Y;Hoek EM;Nel A
纳米材料在医学、技术和经济上都具有广阔的应用前景。关于这些新材料的毒理学特性的知识通常是缺乏的。与此同时，越来越明显的是，一些纳米材料可能对人类和环境有潜在的毒性。基于动物的系统缺乏处理大量新型纳米材料所需的能力，因此我们必须采用高通量的体外方法来管理匆忙的物流，并在需要时使用高含量读数，以获得更深入的信息。为此，高通量筛选（HTS）和高含量筛选（HCS）方法可用于加快安全性分析，其规模与新材料和新性能的扩展速度相称。从HTS/HCS中获得的见解应该有助于我们在生物水平上理解纳米材料危害的原理，并有助于开发设计安全方法。本文旨在全面介绍用于工程纳米材料（enm）安全评估的HTS/HCS方法，包括数据分析和潜在危险材料特性的预测。考虑到目前纳米材料的发展速度，HTS/HCS是一种潜在的有效手段，可以跟上这一领域的快速发展——我们真的没有时间可以浪费了。
Nanomaterials hold great promise for medical, technological and economical benefits. Knowledge concerning the toxicological properties of these novel materials is typically lacking. At the same time, it is becoming evident that some nanomaterials could have a toxic potential in humans and the environment. Animal based systems lack the needed capacity to cope with the abundance of novel nanomaterials being produced, and thus we have to employ in vitro methods with high throughput to manage the rush logistically and use high content readouts wherever needed in order to gain more depth of information. Towards this end, high throughput screening (HTS) and high content screening (HCS) approaches can be used to speed up the safety analysis on a scale that commensurate with the rate of expansion of new materials and new properties. The insights gained from HTS/HCS should aid in our understanding of the tenets of nanomaterial hazard at biological level as well as asset the development of safe-by-design approaches. This review aims to provide a comprehensive introduction to the HTS/HCS methodology employed for safety assessment of engineered nanomaterials (ENMs), including data analysis and prediction of potentially hazardous material properties. Given the current pace of nanomaterial development, HTS/HCS is a potentially effective means of keeping up with the rapid progress in this field – we have literally no time to lose.
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影响因子：
12.8
作者：
Choi, Okkyoung;Deng, Kathy Kanjun;Hu, Zhiqiang
通讯作者：
Hu, Zhiqiang
影响因子：
5
作者：
Andres Rubiolo, Juan;Mithieux, Gilles;Victor Vega, Felix
通讯作者：
Victor Vega, Felix
影响因子：
46.9
作者：
Colvin, VL
通讯作者：
Colvin, VL
DOI：
10.1016/j.ejpb.2005.02.009
发表时间：
2005-08-01
影响因子：
4.9
作者：
Bootz, A;Russ, T;Kreuter, J
通讯作者：
Kreuter, J
影响因子：
4.1
作者：
Chan, JH;Dua, HS;Harris, IM
通讯作者：
Harris, IM