Superiority of a soft tissue-based setup using cone-beam computed tomography over a bony structure-based setup in intensity-modulated radiotherapy for prostate cancer.
Superiority of a soft tissue-based setup using cone-beam computed tomography over a bony structure-based setup in intensity-modulated radiotherapy for prostate cancer.
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DOI：
10.1120/jacmp.v16i5.5448
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发表时间：
2015-09-08
影响因子：
2.1
通讯作者：
Aoyama H
中科院分区：
文献类型：
--
作者：
Sato H;Abe E;Utsunomiya S;Kaidu M;Yamana N;Tanaka K;Ohta A;Obinata M;Liu J;Kawaguchi G;Maruyama K;Ayukawa F;Aoyama H
本研究的目的是测试使用锥形束计算机断层扫描（CBCT）的软组织为基础的装置与使用ExacTrac系统的骨结构为基础的装置在强度调制放疗（IMRT）中前列腺癌的优越性。我们研究了2010年11月至2012年2月期间接受IMRT治疗的20例局限性前列腺癌患者。初始设置后，应用基于骨盆骨结构的设置和ExacTrac系统。之后，使用CBCT和基于软组织的设置。在前后（AP）、上下（SI）和左右（LR）轴上，记录了基于ExacTrac和基于CBCT的设置之间的等中心移位。这种移位被认为是分阶间前列腺移位。治疗后的CBCT每周一次，根据治疗前和治疗后CBCT的等中心坐标来测量前列腺癌内移位。规划目标体积（PTV）边际使用van Herk的方法确定。我们使用CBCT测量了软组织匹配所需的时间和整个治疗时间。在AP方向、SI方向和LR方向上，区域间和区域内位移的大小分别为和。在骨结构和软组织为基础的情况下，PTV边缘在AP方向为7.3 mm和2.7 mm，在SI方向为5.8 mm和2.3 mm，在LR方向为1.9 mm和1.2 mm。尽管使用CBCT的中位时间延长到了5.9分钟，但PTV边缘明显减小。我们发现使用CBCT计算出的以软组织为基础的PTV边缘很小，并且这种排列优于前列腺IMRT中以骨结构为基础的排列。PACS数值：87.19.ru, 87.55.T‐
The purpose of this study was to test the superiority of a soft tissue‐based setup using cone‐beam computed tomography (CBCT) to a bony structure‐based setup using the ExacTrac system in intensity‐modulated radiotherapy (IMRT) for prostate cancer. We studied 20 patients with localized prostate cancer who received IMRT between November 2010 and February 2012. After the initial setup, the pelvic bony structure‐based setup and ExacTrac system were applied. After that, CBCT and a soft tissue‐based setup were used. A shift in the isocenter between the ExacTrac‐based and CBCT‐based setup was recorded in the anterior–posterior (AP), superior–inferior (SI), and left–right (LR) axes. The shift was considered an interfractional prostate shift. Post‐treatment CBCT was also taken once a week to measure the intrafractional prostate shift, based on the coordinates of the isocenter between pre‐ and post‐treatment CBCT. The planning target volume (PTV) margins were determined using van Herk's method. We measured the elapsed time required for soft tissue matching and the entire treatment time using CBCT. The of the inter‐ and intrafractional shifts were and in the AP, and in the SI, and and in the LR directions. The PTV margins in the cases of bony structure‐based and soft tissue‐based setups were 7.3 mm and 2.7 mm in the AP, 5.8 mm and 2.3 mm in the SI, and 1.9 mm and 1.2 mm in the LR directions. Even though the median elapsed time using CBCT was expanded in 5.9 min, the PTV margins were significantly reduced. We found the calculated PTV margins in the soft tissue‐based setup using CBCT were small, and this arrangement was superior to the bony structure‐based setup in prostate IMRT. PACS numbers: 87.19.ru, 87.55.T‐
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DOI：
10.1016/s0360-3016(03)00633-3
发表时间：
2003-11-01
影响因子：
7
作者：
Langen, KM;Pouliot, J;Roach, M
通讯作者：
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影响因子：
3.5
作者：
van Herk, M
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van Herk, M
DOI：
10.1016/j.ijrobp.2006.01.050
发表时间：
2006-06-01
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DOI：
10.1016/j.ijrobp.2008.08.007
发表时间：
2009-06-01
影响因子：
7
作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
Horwich, A