Dormant origins as a built-in safeguard in eukaryotic DNA replication against genome instability and disease development.
Dormant origins as a built-in safeguard in eukaryotic DNA replication against genome instability and disease development.
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DOI：
10.1016/j.dnarep.2017.06.019
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发表时间：
2017-08
期刊：
影响因子：
3.8
通讯作者：
Pederson KD
中科院分区：
文献类型：
--
作者：
Shima N;Pederson KD
DNA复制是细胞增殖的先决条件，然而随着真核细胞的大小和复杂性的扩大，真核细胞忠实地复制其基因组可能越来越具有挑战性。休眠起源现在成为细胞成功完成这一艰巨但重要任务的关键组成部分。从这个角度来看，我们将首先提供一个概述的基本过程真核细胞已经开发出规范的原产地许可和射击。特别关注哺乳动物系统，然后我们将强调休眠起源在防止复制相关基因组不稳定性及其与DNA损伤修复反应中参与肿瘤抑制的蛋白质的功能相互作用中的作用。最后，将讨论原产地许可机制的缺陷对干细胞维持和人类疾病的影响。
DNA replication is a prerequisite for cell proliferation, yet it can be increasingly challenging for a eukaryotic cell to faithfully duplicate its genome as its size and complexity expands. Dormant origins now emerge as a key component for cells to successfully accomplish such a demanding but essential task. In this perspective, we will first provide an overview of the fundamental processes eukaryotic cells have developed to regulate origin licensing and firing. With a special focus on mammalian systems, we will then highlight the role of dormant origins in preventing replication-associated genome instability and their functional interplay with proteins involved in the DNA damage repair response for tumor suppression. Lastly, deficiencies in the origin licensing machinery will be discussed in relation to their influence on stem cell maintenance and human diseases.
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影响因子：
3.3
作者：
Bell SP;Labib K
通讯作者：
Labib K
DNA复制叉的终止：“分手很难做到”。
DOI：
10.1080/19491034.2015.1035843
发表时间：
2015
期刊：
Nucleus (Austin, Tex.)
影响因子：
--
作者：
Bailey R;Priego Moreno S;Gambus A
通讯作者：
Gambus A
影响因子：
4
作者：
Casey, Jillian P.;Nobbs, Michael;Ennis, Sean
通讯作者：
Ennis, Sean
影响因子：
56.9
作者：
Bunz, F;Dutriaux, A;Vogelstein, B
通讯作者：
Vogelstein, B
影响因子：
8
作者：
Chaturvedi, P;Eng, WK;Zhou, BBS
通讯作者：
Zhou, BBS