Factors that Predict Negative Results of QuantiFERON-TB Gold In-Tube Test in Patients with Culture-Confirmed Tuberculosis: A Multicenter Retrospective Cohort Study.
Factors that Predict Negative Results of QuantiFERON-TB Gold In-Tube Test in Patients with Culture-Confirmed Tuberculosis: A Multicenter Retrospective Cohort Study.
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DOI：
10.1371/journal.pone.0129792
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Koh WJ
中科院分区：
文献类型：
--
作者：
Kwon YS;Kim YH;Jeon K;Jeong BH;Ryu YJ;Choi JC;Kim HC;Koh WJ
QuantiFERON-TB Gold In-Tube Test (QFT-GIT) 等干扰素-γ 释放测定旨在检测结核分枝杆菌感染，无论是潜伏还是表现为疾病。然而，大量经培养证实患有结核病 (TB) 的人 QFT-GIT 呈阴性。有关导致假阴性和不确定结果的宿主因素的信息有限。对 2007 年 5 月至 2014 年 2 月期间在六家医院之一接受 QFT-GIT 的 1,264 名 18 岁以上经培养确诊的结核病患者进行了一项多中心回顾性队列研究。排除了人类免疫缺陷病毒感染的患者。临床和实验室数据在韩国收集。在所有患者中，87.6%（1,107/1,264）被诊断为肺结核，12.4%（157/1,264）被诊断为肺外结核。阴性结果率为 14.4% (182/1,264)。以下因素与 QFT-GIT 假阴性结果高度相关：高龄（年龄 ≥ 65 岁，比值比 [OR] 1.57，95% 置信区间 [CI] 1.03–2.39）、胸部 X 线检查确定的双侧疾病（OR 1.75，95% CI 1.13–2.72）、恶性肿瘤（OR 2.42，95% CI） 1.30–4.49）和淋巴细胞减少（淋巴细胞总数 < 1.0 × 109/L，OR 1.86，95% CI 1.21–2.87）。因此，对于具有这些宿主危险因素（例如老年人、胸部X光检查显示双侧疾病、恶性肿瘤或淋巴细胞减少症）的患者，需要谨慎解释 QFT-GIT 结果。
Interferon-γ release assays such as the QuantiFERON-TB Gold In-Tube Test (QFT-GIT) are designed to detect Mycobacterium tuberculosis infections, whether latent or manifesting as disease. However, a substantial number of persons with culture-confirmed tuberculosis (TB) have negative QFT-GITs. Information on host factors contributing to false-negative and indeterminate results are limited. A multicenter retrospective cohort study was performed with 1,264 culture-confirmed TB patients older than 18 years who were subjected to the QFT-GIT at one of the six hospitals between May 2007 and February 2014. Patients with human immunodeficiency virus infection were excluded. Clinical and laboratory data were collected in South Korea. Of all patients, 87.6% (1,107/1,264) were diagnosed with pulmonary TB and 12.4% (157/1,264) with extrapulmonary TB. The rate of negative results was 14.4% (182/1,264). The following factors were highly correlated with false-negative results in the QFT-GIT: advanced age (age ≥ 65 years, odds ratio [OR] 1.57, 95% confidence interval [CI] 1.03–2.39), bilateral disease as determined by chest radiography (OR 1.75, 95% CI 1.13–2.72), malignancy (OR 2.42, 95% CI 1.30–4.49), and lymphocytopenia (total lymphocyte count < 1.0 × 109/L, OR 1.86, 95% CI 1.21–2.87). Consequently, QFT-GIT results need to be interpreted with caution in patients with these host risk factors such as the elderly, bilateral disease on chest radiography, or malignancy, or lymphocytopenia.
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影响因子：
6.4
作者：
Kumar, Nathella Pavan;George, Parakkal Jovvian;Babu, Subash
通讯作者：
Babu, Subash
DOI：
10.5588/ijtld.13.0644
发表时间：
2014-04-01
影响因子：
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作者：
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作者：
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影响因子：
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作者：
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Pai, Madhukar
DOI：
10.1016/0041-3879(80)90001-x
发表时间：
1980-01-01
期刊：
TUBERCLE
影响因子：
--
作者：
ABER, VR;ALLEN, BW;KEYES, AB
通讯作者：
KEYES, AB