Signal Variability and Cognitive Function in Older Long-Term Survivors of Breast Cancer with Exposure to Chemotherapy: A Prospective Longitudinal Resting-State fMRI Study.
Signal Variability and Cognitive Function in Older Long-Term Survivors of Breast Cancer with Exposure to Chemotherapy: A Prospective Longitudinal Resting-State fMRI Study.
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DOI：
10.3390/brainsci12101283
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发表时间：
2022-09-23
期刊：
影响因子：
3.3
通讯作者：
Dale, William
中科院分区：
文献类型：
--
作者：
Chen, Bihong T.;Chen, Zikuan;Deng, Frank;Patel, Sunita K.;Sedrak, Mina S.;Root, James C.;Ahles, Tim A.;Razavi, Marianne;Kim, Heeyoung;Sun, Can-Lan;Dale, William
关键词：
本研究的目的是评估化疗对老年乳腺癌长期生存者脑功能静息状态信号变异性和认知功能的影响。这项前瞻性纵向研究入组了年龄≥ 65岁的女性，这些女性是暴露于化疗（CH）后的乳腺癌幸存者、年龄匹配的未暴露于化疗的幸存者和健康对照。参与者在入组时（时间点1，TP 1）和两年后（时间点2，TP 2）完成静息态脑功能MRI和神经认知测试。TP 1时，三组中每组有20名参与者。CH组SDBOLD显著降低，（血氧水平依赖性信号变异性标准差）（MNI时，ΔSDBOLD = −0.0018，p = 0.0085，q（pFDR）= 0.043（42，-76，17））和右侧颞中回（ΔSDBOLD =-0.0021，p = 0.0006，q（pFDR）= 0.001，MNI（63，-39，-12））。TP 1时，CH组右侧枕下回（相关系数r =-0.84，p = 0.001，q（pFDR）= 0.016）和右侧颞中回（r =-0.88，p = 0.000，q（pFDR）= 0.017）的结晶综合评分与SDBOLD值之间呈负相关。SDBOLD可能是一个潜在的有用的神经影像学标记物，为老年长期生存的乳腺癌暴露于化疗。
The purpose of this study was to assess the effect of chemotherapy on brain functional resting-state signal variability and cognitive function in older long-term survivors of breast cancer. This prospective longitudinal study enrolled women age ≥ 65 years of age who were breast cancer survivors after exposure to chemotherapy (CH), age-matched survivors not exposed to chemotherapy, and healthy controls. Participants completed resting-state functional brain MRI and neurocognitive testing upon enrollment (timepoint 1, TP1) and again two years later (timepoint 2, TP2). There were 20 participants in each of the three groups at TP1. The CH group showed a significant decrease in SDBOLD (blood-oxygen-level-dependent signal variability in standard deviation) in the right middle occipital gyrus (ΔSDBOLD = −0.0018, p = 0.0085, q (pFDR) = 0.043 at MNI (42, −76, 17)) and right middle temporal gyrus (ΔSDBOLD = −0.0021, p = 0.0006, q (pFDR) = 0.001 at MNI (63, −39, −12)). There were negative correlations between the crystallized composite scores and SDBOLD values at the right inferior occipital gyrus (correlation coefficient r = −0.84, p = 0.001, q (pFDR) = 0.016) and right middle temporal gyrus (r = −0.88, p = 0.000, q (pFDR) = 0.017) for the CH group at TP1. SDBOLD could be a potentially useful neuroimaging marker for older long-term survivors of breast cancer with exposure to chemotherapy.
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影响因子：
3.6
作者：
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