Clinicopathological characteristics and survival in lung signet ring cell carcinoma: a population-based study.
Clinicopathological characteristics and survival in lung signet ring cell carcinoma: a population-based study.
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肺印戒细胞癌的临床病理学特征和生存：一项基于人群的研究。
DOI：
10.17305/bjbms.2020.5454
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发表时间：
2021-12-01
影响因子：
3.4
通讯作者：
Meng S
中科院分区：
文献类型：
--
作者：
Cai Y;Xie Y;Xiong Y;Guan W;Pu Y;Wang D;Xu M;Meng S
肺印戒细胞癌（LSRCC）是一种非常罕见的肺癌类型，其临床特征和预后仍有待进一步研究。为了探索与LSRCC相关的临床病理学和生存相关因素，我们对2001年至2015年的监测、流行病学和最终结果（SEER）登记中包含的数据进行了一项基于人群的大型队列分析。共有752例LSRCC和7518例肺粘液腺癌（LMAC）患者纳入我们的分析，诊断时的平均年龄分别为63.8岁和67.5岁。LSRCC患者比LMAC患者更有可能患有远端疾病（72.1% vs. 45.8%，p < 0.0001），高病理级别肿瘤（40.6%对10.8%，p < 0.0001），接受过化疗（62.1% vs. 39.9%，p<0.0001），男性（52.7% vs. 48.5%，p = 0.03），且年龄< 40岁（3.3% vs. 1.3%，p = 0.022），而他们接受手术治疗的可能性较小（52.4% vs. 77.0%，p < 0.0001）。LSRCC和LMAC患者的中位总生存期（OS）分别为8个月和18个月（p < 0.0001），尽管在调整混杂变量后这些差异并不显著。与患者预后良好相关的独立因素包括原发灶位于中肺叶或下肺叶、接受手术和接受化疗。然而，年龄≥80岁、高级别、远处总结期疾病和T4期疾病与预后不良相关。患者年龄、肿瘤分级、原发肿瘤部位、总结分期、T分期、手术和化疗均与LSRCC患者预后显著相关。
Lung signet-ring cell carcinoma (LSRCC) is a very rare type of lung cancer, the clinical characteristics, and prognosis of which remain to be clarified. In order to explore the clinicopathological and survival-related factors associated with LSRCC, we performed a large population-based cohort analysis of data included in the Surveillance, Epidemiology, and End Results (SEER) registry from 2001 to 2015. A total of 752 LSRCC and 7518 lung mucinous adenocarcinoma (LMAC) patients were incorporated into our analysis, with respective mean ages of 63.8 and 67.5 years at the time of diagnosis. LSRCC patients were significantly more likely than LMAC patients to have distant-stage disease (72.1% vs. 45.8%, p < 0.0001), tumors of a high pathological grade (40.6% vs. 10.8%, p < 0.0001), have undergone chemotherapy (62.1% vs. 39.9%, p<0.0001), be male (52.7% vs. 48.5%, p = 0.03), and be < 40 years old (3.3% vs. 1.3%, p = 0.022), whereas they were less likely to have undergone surgical treatment (52.4% vs. 77.0%, p < 0.0001). LSRCC and LMAC patients exhibited median overall survival (OS) duration of 8 and 18 months (p < 0.0001), respectively, although these differences were not significant after adjusting for confounding variables. Independent factors associated with a favorable patient prognosis included a primary site in the middle or lower lung lobe, underwent surgery, and underwent chemotherapy. However, age ≥80 years, higher grade, distant summary stage disease, and T4 stage disease were linked to poor prognosis. Patient age, tumor grade, primary tumor site, summary stage, T stage, surgery, and chemotherapy were all significantly associated with LSRCC patient prognosis.
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影响因子：
6.2
作者：
Orvieto, Enrico;Maiorano, Eugenio;Viale, Giuseppe
通讯作者：
Viale, Giuseppe
影响因子：
20.4
作者：
Levy, Antonin;Le Pechoux, Cecile;Faivre-Finn, Corinne
通讯作者：
Faivre-Finn, Corinne
影响因子：
6.4
作者：
Castro, CY;Moran, CA;Suster, S
通讯作者：
Suster, S
影响因子：
20.4
作者：
Xie, Dong;Marks, Randolph;Yang, Ping
通讯作者：
Yang, Ping
影响因子：
7.3
作者：
Tsuta, K;Ishii, G;Ochiai, A
通讯作者：
Ochiai, A